404576-89-2Relevant academic research and scientific papers
Fluorinated butanolides and butenolides: Part 8. 2-(Trifluoromethyl)butan-4-olides by synthesis from methyl 3,3,3-trifluoropyruvate as building block
Paleta, Old?ich,Pale?ek, Ji?í,Dolensky, Bohumil
, p. 175 - 184 (2001)
2-Hydroxy-2-trifluoromethylbutan-4-olides (8-10) were prepared by a four step synthesis starting from a ketone and methyl 3,3,3-trifluoropyruvate (1) as a building block. Uncatalyzed chemospecific aldolization of ketones with 1 afforded 2 hydroxy-4-oxoest
