404597-93-9Relevant articles and documents
Neuroregenerative Potential of Prenyl- And Pyranochalcones: A Structure-Activity Study
Aigner, Ludwig,Bieler, Lara,Couillard-Despres, Sebastien,Priglinger, Eleni,Riepl, Herbert M.,Urmann, Corinna
supporting information, p. 2675 - 2682 (2021/10/12)
Loss of neuronal tissue is a hallmark of age-related neurodegenerative diseases. Since adult neurogenesis has been confirmed in the human brain, great interest has arisen in substances stimulating the endogenous neuronal regeneration mechanism based on ad
BENZOTHIOPHENE DERIVATIVE HAVING ANTI-CANCER EFFECT
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Paragraph 0012, (2018/09/25)
PROBLEM TO BE SOLVED: To provide a novel compound that has an excellent anti-cancer effect. SOLUTION: Provided is a benzothiophene derivative represented by formula (1), or a pharmaceutically acceptable salt thereof. [R1 is H, OH, a halogeno group, a C1 to 12 alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylamino group or an alkylthio group, a substituted/unsubstituted aryl group, a substituted/unsubstituted benzyl group, or a substituted/unsubstituted carbon ring or heterocyclic ring condensed to 5-6 position; R2 is H, OH, a halogeno group, a C1 to 12 alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylamino group or an alkylthio group; a substituted/unsubstituted aryl group or a substituted/unsubstituted benzyl group.] SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPO&INPIT
Construction of 2-substituted-3-functionalized benzofurans via intramolecular heck coupling: Application to enantioselective total synthesis of daphnodorin B
Yuan, Hu,Bi, Kai-Jian,Li, Bo,Yue, Rong-Cai,Ye, Ji,Shen, Yun-Heng,Shan, Lei,Jin, Hui-Zi,Sun, Qing-Yan,Zhang, Wei-Dong
supporting information, p. 4742 - 4745 (2013/10/08)
A novel approach was developed for the synthesis of 2-substituted-3- functionalized benzofurans, using an intramolecular Heck reaction which was further applied in the first enantioselective total synthesis of Daphnodorin B.
The first total synthesis of glycyrol
Jin, Ying Lan,Kim, Sanghee,Kim, Yeong Shik,Kim, Soon-Ai,Kim, Hak Sung
supporting information; scheme or table, p. 6835 - 6837 (2009/04/07)
We report the first total synthesis of glycyrol. Glycyrol, isolated from Glycyrrhizae Radix, has a unique skeleton of a benzofuran coumarin. The key steps are Smiles rearrangement and selective introduction of prenyl and O-methyl groups. The first application of a novel precursor for Smiles rearrangement, 3-benzyloxy-substituted (diacetoxyiodo)benzene, showed the synthetic possibility for diverse precursors. The introduction of a benzyl protecting group was important because selective deprotection was hard due to the low solubility of intermediates.
A facile synthetic route to two chalcones
Du, Zhenting,She, Xuegong,Ma, Junying,Wang, Zikun,Wu, Huafang,Li, Yang,Pan, Xinfu
, p. 45 - 46 (2007/10/03)
A facile total synthetic route to two naturally occurring chalcones with a partially methylated structure has been achieved in good yield. The key step was selective deprotection of a MOM ether in the aryl methyl ether 6 by a solid phase reaction.
