4046-09-7

Basic information

• Product Name: Ethanone, 1-(1-phenylcyclopentyl)-
• CAS NO: 4046-09-7
• Molecular Formula: C13H16O
• Molecular Weight: 188.269
• Mol File: 4046-09-7.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(1-phenylcyclopentyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(1-phenylcyclopentyl)-(4046-09-7)
• EPA Substance Registry System: Ethanone, 1-(1-phenylcyclopentyl)-(4046-09-7)

Safety Data

• Hazardous Substances Data: 4046-09-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(1-phenylcyclopentyl)is used as a chemical intermediate for the synthesis of various pharmaceutical compounds due to its unique ketone and phenylcyclopentyl structure, which can be utilized in the development of new drugs with specific therapeutic properties.
Used in Fragrance Industry:
Ethanone, 1-(1-phenylcyclopentyl)is used as a fragrance ingredient for creating unique scents and perfumes, leveraging its aromatic properties derived from the phenyl group attached to the cyclopentane ring.
Used in Organic Synthesis:
Ethanone, 1-(1-phenylcyclopentyl)is used as a building block in organic synthesis for constructing complex organic molecules, taking advantage of its reactive ketone group and the cyclopentane ring's structural features.
Further research and studies are essential to fully understand the properties and potential uses of Ethanone, 1-(1-phenylcyclopentyl)-, and to explore its applications across various industries.

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 103-79-7 1-phenyl-acetone 
• 77-57-6 1-phenyl-1-cyclopentanecarbonitrile 
• 75-16-1 methylmagnesium bromide 
• 60021-45-6 Methyl-(1-phenyl-2-cyclopentenyl)-keton 
• 154382-30-6 β-oxo-1-phenylcyclopentanepropanoic acid ethyl ester 
• 77-55-4 1-phenyl-1-cyclopentanecarboxylic acid 
• 917-54-4 methyllithium 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 80606-01-5 1-Phenylcyclopentylmethylketoxim-pikrat 
• 80606-91-3 1-Phenylcyclopentylmethylketoxim 
• 101266-82-4 1-(1-phenyl-cyclopentyl)-ethanol 
• 700-88-9 cyclopentylbenzene 

Relevant articles and documents

Water-Soluble Calixarenes as New Inverse Phase-Transfer Catalysts. Their Scope in Aqueous Biphasic Alkylations and Mechanistic Implications

Alkylation reactions of active methylene compounds, alcohols and phenols with alkyl halides in aqueous NaOH solution can be carried out without the need for any added organic solvents in most cases. The water-soluble calix[n]arenes, which contain trimethylammoniomethyl groups on the upper rim, were used as inverse phase-transfer catalysts, resulting in the corresponding alkylated products in good to high yields. The scope of this methodology in aqueous biphasic alkylation reactions and the mechanistic implications are discussed.

Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel β-ketoamides as hypocholesterolemic agents

A study of structure-activity relationships of substituted β-ketoamide ACAT inhibitors I and II was performed. The results of this study suggest that whereas the β-keto group was tolerated with no loss in activity, β- hydroxy and oxime moieties led to significantly reduced activity in vitro and in vivo. The most potent inhibitor from the acyclic series (I) (11, IC50 = 0.006 μM) contained a C-13 alkyl chain. This compound reduced plasma total cholesterol by 38% and 66% at 3 and 30 mg/kg, respectively, in cholesterol- fed rats. Dimethylation α to the anilide core (5) and subsequent N- methylation of the amide NH (6) decreased in vitro potency significantly. It was also found that high potency was retained with inhibitors which incorporated the carbonyl into a lactam ring (II).

Wanderungstendenzen cyclischer, polycyclischer und methylverzweigter Alkylreste bei der Beckmann-Umlagerung

The migration aptitudes of polycyclic bridgehead groups, cycloalkyl groups as well as of β-, γ- and δ-branched alkyl groups in the Chapman variant of the Beckmann rearrangement were determined.From these data it is concluded that at transition state 2 the migrating group is not resembling a planarised carbenium ion R+, but rather a pentacoordinated carbonium ion structure.Because only small geometrical changes occur in the migrating group vertical stabilisation of charge at transition state is believed to have significant influence on the migration aptitudes.