40468-93-7

Upstream product

• 43017-15-8 9-phenyl-9-phosphabicyclo[4.2.1]nonatriene oxide 
• 644-97-3 Dichlorophenylphosphine 
• 477773-51-6 cyclooctatetraene 
• 13887-07-5 anti-9-phenyl-9-phosphabicyclo<4.2.1>nona-2,4,7-trien 
• 7289-58-9 9-phenyl-9-phosphabicyclo<6.1.0>nona-2,4,6-triene 
• 629-20-9 1,3,5,7-cyclooctatetraene 

Downstream Products

• 40468-89-1 9,9-diphenyl-9-phospha-bicyclo[4.2.1]nonanium; bromide 
• 13945-86-3 9-phenyl-9-phosphabicyclo<4.2.1>nonane 

Relevant academic research and scientific papers

A Bridged Tetrahydrophosphole Ylide Derived from 9-Phenylphosphabicyclononane: A Reagent for E-Selective Wittig Reactions

The bicyclic ylide 4 reacts with aldehydes to afford the E-alkenes.Selectivity is 94 - 6percent E for unbranched aldehydes, but the selectivity decreases with increasing α-branching.Ylide 4 is the first E-selective, nonstabilized ylide that allows efficient utilization of the P-alkyl substituent.

METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS

A method for increasing the rate of phosphine oxide reduction, preferably during a Wittig reaction comprising use of an acid additive is provided. A room temperature catalytic Wittig reaction (CWR) the rate of reduction of the phosphine oxide is increased due to the addition of the acid additive is described. Furthermore, the extension of the CWR to semi-stabilized and non-stabilized ylides has been accomplished by utilization of a masked base and/or ylide-tuning.