40473-53-8Relevant articles and documents
A base-promoted cascade reaction of α,β-unsaturated: N -tosylhydrazones with o -hydroxybenzyl alcohols: Highly regioselective synthesis of N-sec -alkylpyrazoles
Chen, Lian-Mei,Zhao, Juan,Xia, An-Jie,Guo, Xiao-Qiang,Gan, Ya,Zhou, Chuang,Yang, Zai-Jun,Yang, Jun,Kang, Tai-Ran
supporting information, p. 8561 - 8570 (2019/10/02)
An efficient method for the synthesis of N-sec-alkylpyrazoles through a base-promoted cascade cyclization/Michael addition reaction of α,β-unsaturated N-tosylhydrazones with ortho-hydroxybenzyl alcohols has been developed. The desired products containing di- or triaryl groups at the same carbon atom were afforded in good to excellent yields with excellent regioselectivities (>20:1). Moreover, a three-component reaction of ortho-hydroxybenzyl alcohols, α,β-unsaturated N-tosylhydrazones and saturated N-tosylhydrazones also took place to afford pyrazoles in good yields. This reaction offers a new route to triarylmethanes with a simple operation and is applicable for large-scale synthesis.
Mannich Bases, XXI: Exchange Reactions of Phenolic Mannich Bases
Moehrle, Hans,Miller, Christoph
, p. 229 - 236 (2007/10/02)
Various p-substituted phenolic Mannich bases (and to a minor degree o-substituted derivatives) form alcohols and ethers when heated in aqueous alcohols in the presence of Na2EDTA or acetic acid.The reaction proceeds with amine elimination and subsequent addition of the solvent to the resulting quinone methide.
