40474-21-3

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 98-83-9 isopropenylbenzene 
• 124-38-9 carbon dioxide 
• 55091-64-0 1-methyl-1-phenyl-2-bromocyclopropane 
• 55091-64-0 trans-1-bromo-2-methyl-2-phenyl-cyclopropane 
• 36122-28-8 ethyl 2-methyl-2-phenylcyclopropane-1-carboxylate 
• 65051-83-4 3-methyl-3-phenylcyclopropene 
• 29161-81-7 2-methyl-2-phenylcyclopropanecarbonitrile 
• 82095-92-9 (1S,2S)-2-carboxy-1-methyl-1-phenylcyclopropane 
• 160497-39-2 ethyl (1S,2R)-2-methyl-2-phenylcyclopropane-1-carboxylate 
• 335593-39-0 ethyl (1R,2R)-2-methyl-2-phenylcyclopropane-1-carboxylate 
• 29161-89-5 cis-2-Methyl-2-phenyl-cyclopropan-carbonsaeure-⁽¹⁾ 

Downstream Products

• 19009-66-6 2-Amino-1-methyl-1-phenyl-cyclopropan 
• 29161-85-1 (1S*,2S*)-2-methyl-2-phenylcyclopropane-1-carboxamide 
• 81639-95-4 2-methyl-2-phenylcyclopropane-1-carbonitrile 
• 81639-93-2 2-Methyl-2-phenyl-cyclopropanecarboxylic acid amide 

Relevant academic research and scientific papers

OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO

Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Amide-Group-Directed Protonolysis of Cyclopropane: An Approach to 2,2-Disubstituted Pyrrolidines

Regioselective protonolytic C-C bond cleavage of acylated aminomethyl cyclopropanes can be achieved using trifluoroacetic acid. The intermediate tertiary carbenium ion undergoes an intramolecular amination to give 2,2-substituted pyrrolidines. The strength of the acid and the amine substituent are important factors to achieve high regioselectivity, suggesting intramolecular proton transfer from the protonated amide function. Preliminary mechanistic studies revealed that cyclopropane cleavage proceeds with retention of configuration at the carbon to which the proton is attached. This observation is consistent with the "edge" protonation trajectory of the C-C bond.

Nickel-Catalyzed Reductive Carboxylation of Cyclopropyl Motifs with Carbon Dioxide

A nickel-catalyzed reductive carboxylation technique for the synthesis of cyclopropanecarboxylic acids has been developed. This user-friendly and mild transformation operates at atmospheric pressure of carbon dioxide and utilizes either organic halides or alkene precursors, thus representing the first example of catalytic reductive carboxylation of secondary counterparts lacking adjacent π-components.

The Photochemistry of 1-Cyano-2-methyl-3-phenylpropene and Ring substituted Derivatives

The E- and Z-isomers of 1-cyano-2-methyl-3-phenylpropene and ring-substituted derivatives of the E-isomer, are shown to fluoresce and undergo Z-E-isomerization and di-?-methane rearrangement on irradiation.The rate constants for these processes, obtained from fluorescence lifetimes and quantum yields, can be analysed in terms of an initial interaction between the two ? systems, facilitated by partial charge-transfer, followed by two diverging pathways, one, towards a diradicaloid species leading to cyclopropane formation, the other towards a 'zwitterionic' species and relaxation to the ground state and resulting in singlet state Z-E-isommerization.