40484-98-8

Basic information

• Product Name: 1-(2-methyl-1-benzofuran-3-yl)ethanone
• Synonyms: 1-(2-Methyl-1-benzofuran-3-yl)ethanone; ethanone, 1-(2-methyl-3-benzofuranyl)-
• CAS NO: 40484-98-8
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.1959
• Mol File: 40484-98-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 52 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 277.6°C at 760 mmHg
• Flash Point: 124.5°C
• Density: 1.13g/cm³
• Vapor Pressure: 0.00449mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: 1-(2-methyl-1-benzofuran-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methyl-1-benzofuran-3-yl)ethanone(40484-98-8)
• EPA Substance Registry System: 1-(2-methyl-1-benzofuran-3-yl)ethanone(40484-98-8)

Safety Data

• Hazardous Substances Data: 40484-98-8(Hazardous Substances Data)

Usage

Type of compound

Ketone

Structural features

Contains a benzofuran ring
Methyl group attached to the second carbon atom

Applications

Used in the synthesis of various organic compounds
Found in research and industrial applications

Physical appearance

Pale yellow

Odor

Distinctive

Safety precautions

Handle with care due to potential hazards

Field of use

Chemistry and pharmaceuticals

Versatility

Versatile compound with various applications

Upstream product

• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 15387-78-7 3,3-dihydroxy-2,4-pentanedione 
• 108-94-1 cyclohexanone 
• 106915-02-0 3-(cyclohex-2-en-1-yl)pentane-2,4-dione 
• 583-55-1 1-Bromo-2-iodobenzene 
• 123-54-6 acetylacetone 
• 271-89-6 1-benzofurane 
• 4846-21-3 O-phenylhydroxylamine 
• 36754-60-6 2-(chloromethyl)-1-benzofuran 
• 496-41-3 Benzofuran-2-carboxylic acid 
• 55038-01-2 benzofuran-2-yl-methanol 
• 93680-67-2 methyl 3-acetylbenzofuran-2-ylacetate 
• 39581-61-8 benzofuran-2-yl-acetic acid methyl ester 
• 93680-68-3 3-acetylbenzofuran-2-ylacetic acid 

Downstream Products

• 1374410-75-9 1-(3,5-dimethoxyphenyl)-1,2-bis(2-methylbenzofuran-3-yl)-2-oxoethyl acetate 
• 124617-49-8 1-(2-Methyl-benzofuran-3-yl)-3-(4-phenyl-piperazin-1-yl)-propan-1-ol 
• 124617-51-2 2-Bromo-1-(2-methyl-benzofuran-3-yl)-ethanone 
• 124617-50-1 2,2-Dibromo-1-(2-methyl-benzofuran-3-yl)-ethanone 
• 3265-74-5 2-methyl-1-benzofuran-3-carboxylic acid 
• 101450-87-7 1-(2-methyl-benzofuran-3-yl)-ethanone-(2,4-dinitro-phenylhydrazone) 

Relevant articles and documents

De novo synthesis of benzofurans via trifluoroacetic acid catalyzed cyclization/oxidative aromatization cascade reaction of 2-hydroxy-1,4-diones

A facile, one-pot method for the de novo synthesis of benzofurans from 2-hydroxy-1,4-diones is described. Using trifluoroacetic acid (TFA) as the catalyst and N-bromobutanimide (NBS) as the oxidant, 2-hydroxy-1,4-diones underwent a cyclization/oxidative a

Synthesis of oxacalothrixin B and its analogues involving iodine/TBHP-mediated electrocyclization

The total synthesis of oxacalothrixins, an isostere of biologically important carbazoloquinone alkaloid, calothrixin B was achieved from 2-acetyl-3-methylbenzofuran. An iodine/TBHP-mediated oxidative cyclization of benzofuranyl-enamine has been employed as a key step to synthesize, the crucial intermediate 1-hydroxy dibenzofurancarbaldehyde. The latter upon reductive cyclization followed by PIDA-mediated oxidation furnished oxacalothrixin B and its analogues.

Cu-catalyzed reaction of 1,2-dihalobenzenes with 1,3-cyclohexanediones for the synthesis of 3,4-dihydrodibenzo[b,d]furan-1(2H)-ones

The Cu(I)-catalyzed reaction of 1-bromo-2- iodobenzenes and other 1,2-dihalobenzenes with 1,3-cyclohexanediones in DMF at 130 °C using Cs 2CO3 as a base and pivalic acid as an additive selectively delivers 3,4- dihydrodibenzo[b,d]fur