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Phenoxyamine is a versatile chemical compound belonging to the class of arylamines, characterized by the presence of both an amino group and a phenyl group attached to an oxygen atom. It is commonly synthesized by coupling an aniline with a phenol, and its wide range of applications in various industries, including pharmaceutical, agrochemical, dye and pigment production, polymer stabilization, and coordination chemistry, makes it a valuable compound in scientific research.

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  • 4846-21-3 Structure
  • Basic information

    1. Product Name: Phenoxyamine
    2. Synonyms: Phenoxyamine;(Aminooxy)benzene
    3. CAS NO:4846-21-3
    4. Molecular Formula: C6H7NO
    5. Molecular Weight: 145.59
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4846-21-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 72-72.5 °C(Press: 7 Torr)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.084±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 1.73±0.70(Predicted)
    10. CAS DataBase Reference: Phenoxyamine(CAS DataBase Reference)
    11. NIST Chemistry Reference: Phenoxyamine(4846-21-3)
    12. EPA Substance Registry System: Phenoxyamine(4846-21-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4846-21-3(Hazardous Substances Data)

4846-21-3 Usage

Uses

Used in Pharmaceutical Industry:
Phenoxyamine is used as a building block in organic synthesis for the development of various pharmaceutical compounds due to its unique chemical properties and reactivity.
Used in Agrochemical Industry:
Phenoxyamine is used as a key component in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Dye and Pigment Production:
Phenoxyamine is used as a precursor in the production of dyes and pigments, enabling the creation of a diverse range of colorants for various applications.
Used in Polymer Manufacturing:
Phenoxyamine is used as a stabilizer in the manufacturing of polymers, enhancing their stability and performance in various applications.
Used in Coordination Chemistry:
Phenoxyamine is used as a ligand in coordination chemistry, facilitating the formation of coordination complexes with metal ions for various applications.
Used in Antimicrobial Research:
Phenoxyamine has been studied for its potential antimicrobial properties, making it a promising candidate for the development of new antimicrobial agents.
Used in Antitumor Research:
Phenoxyamine has been investigated for its potential antitumor properties, offering insights into the development of novel cancer treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 4846-21-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,4 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4846-21:
(6*4)+(5*8)+(4*4)+(3*6)+(2*2)+(1*1)=103
103 % 10 = 3
So 4846-21-3 is a valid CAS Registry Number.

4846-21-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name O-phenyl-hydroxylamine

1.2 Other means of identification

Product number -
Other names o-(Phenyl)Hydroxylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4846-21-3 SDS

4846-21-3Relevant articles and documents

Unexpected Sole Enol-Form Emission of 2-(2′-Hydroxyphenyl)oxazoles for Highly Efficient Deep-Blue-Emitting Organic Electroluminescent Devices

Li, Bijin,Tang, Guoqiang,Zhou, Linsen,Wu, Di,Lan, Jingbo,Zhou, Liang,Lu, Zhiyun,You, Jingsong

, (2017)

Considerable efforts have been devoted to the development of highly efficient blue light-emitting materials. However, deep-blue fluorescence materials that can satisfy the Commission Internationale de l'Eclairage (CIE) coordinates of (0.14, 0.08) of the N

Determination of band edges and their influences on photocatalytic reduction of nitrobenzene by bulk and exfoliated g-C3N4

Challagulla, Swapna,Payra, Soumitra,Chakraborty, Chanchal,Roy, Sounak

, p. 3174 - 3183 (2019)

Thermally and chemically exfoliated metal-free semiconducting g-C3N4 are synthesized from bulk g-C3N4. Thorough characterization of the synthesized materials is performed with the help of XRD, FTIR, FE-SEM, PL, surface area analysis and DRS to probe differences in structural, morphological and optical properties between thermally and chemically exfoliated g-C3N4. The synthesized materials are exposed to light for photocatalytic reduction of nitrobenzene. The complete reduction reaction mechanism and product selectivity over the synthesized catalysts are studied in this report. The rate of reduction of nitrobenzene is found to be higher with thermally exfoliated g-C3N4, and the selectivity of aniline is found to be higher in the case of chemical exfoliated g-C3N4. The differences in the reactivity are explained in terms of structure, surface morphologies and band edge positions.

Hexafluoroisopropanol (HFIP)-prompted rearrangement of N-phenoxysulfonamides for the direct assembly of ortho-sulfonamide phenols: A combined experimental and computational study

Wang, Yi,Chen, Xiaoli,Lin, Shuang,Gao, Hui,Liu, Fu-Xiaomin,Zhou, Zhi,Yi, Wei

supporting information, (2022/01/08)

ortho-Sulfonamide phenols represent a class of attractive structural motifs in medicinal and synthetic chemistry. Herein an efficient metal-free rearrangement reaction has been developed for the construction of ortho-sulfonamide phenols via HFIP-prompted

Total Synthesis of (±)-Impatien A via Aza-Heck Cyclization

Korch, Katerina M.,Watson, Donald A.

supporting information, p. 7285 - 7289 (2021/09/14)

The first total synthesis of the natural product impatien A is described. This concise synthesis features an aza-Heck cyclization to construct the complex spirocyclic ring system and provides a rare example of the use of aza-Heck cyclizations in complex molecule synthesis. To enable this key cyclization of an electrophilic nitrogen atom with a tetrasubstituted alkene, we utilized high-throughput experimentation to identify a new ligand and ultimately deliver impatien A in seven steps from known compounds.

An Activity-Based Sensing Fluorogenic Probe for Monitoring Ethylene in Living Cells and Plants

Chen, Yiliang,Guo, Duojing,Jing, Maofeng,Li, Ji,Li, Yu,Liu, Hao,Wang, Biao,Wei, Lirong,Yan, Wei,Ye, Yonghao,Yu, Na,Zhao, Jing,Zheng, Ying

supporting information, p. 21934 - 21942 (2021/08/30)

Ethylene (ET) is an important gaseous plant hormone. It is highly desirable to develop fluorescent probes for monitoring ethylene in living cells. We report an efficient RhIII-catalysed coupling of N-phenoxyacetamides to ethylene in the presenc

Synthesis of ortho-phenolic sulfilimines via an intermolecular sulfur atom transfer cascade reaction

Ren, Yan,Song, Yinan,Xiong, Feng,Xu, Shaojian,Zhang, Linxing,Zhang, Xinhao,Zuo, Yingying

supporting information, p. 3799 - 3803 (2020/06/08)

To expand the toolbox for the synthesis of ortho-phenolic sulfilimines, sigmatropic rearrangements were introduced to the field of sulfilimine chemistry. Herein we report a N-H sulfenylation/[2,3]-sigmatropic rearrangement cascade reaction. This mild reaction enables commercially available thiols to serve as the sulfenylation reagent and generates water as the sole byproduct. Moreover, the reaction has a wide substrate scope and can be conducted on a gram scale with excellent reaction efficiency.

Rhodium(III)-Catalyzed Enantio- and Diastereoselective C?H Cyclopropylation of N-Phenoxylsulfonamides: Combined Experimental and Computational Studies

Zheng, Guangfan,Zhou, Zhi,Zhu, Guoxun,Zhai, Shuailei,Xu, Huiying,Duan, Xujing,Yi, Wei,Li, Xingwei

supporting information, p. 2890 - 2896 (2020/01/24)

Cyclopropane rings are a prominent structural motif in biologically active molecules. Enantio- and diastereoselective construction of cyclopropanes through C?H activation of arenes and coupling with readily available cyclopropenes is highly appealing but

Pyrazole formaldoxime ether compound as well as preparation method and application thereof

-

Paragraph 0055-0057, (2020/09/09)

The invention discloses a pyrazole formaldoxime ether compound as well as a preparation method and application thereof. The structural formula of the pyrazole formaldoxime ether compound is shown as the following formula I shown in the specification, wherein in the formula I, R1 represents at least one of hydrogen, C1-C6 alkyl, C1-C6 alkyl monosubstituted by halogen and C1-C6 alkyl polysubstitutedby halogen; R2 represents at least one of hydrogen, C1-C6 alkyl, C1-C6 alkyl monosubstituted or polysubstituted by halogen, aryl and substituted aryl; R3 represents at least one of phenyl, benzyl, substituted benzyl, substituted phenyl, an unsubstituted nitrogen and/or oxygen-containing heterocyclic group, a substituted nitrogen and/or oxygen-containing heterocyclic group, an unsubstituted C3-C8cycloalkyl group and a substituted C3-C8 cycloalkyl group. The pyrazole formaldoxime ether compound takes oxime ether as a main skeleton structure, is simple in preparation method, can be used for efficiently preventing and treating fungal diseases and oomycete diseases of farmland crops, and can be used for disease resistance management.

Dual Directing-Groups-Assisted Redox-Neutral Annulation and Ring Opening of N-Aryloxyacetamides with 1-Alkynylcyclobutanols via Rhodium(III)-Catalyzed C-H/C-C Activations

Pan, Jin-Long,Liu, Chang,Chen, Chao,Liu, Tuan-Qing,Wang, Man,Sun, Zhenliang,Zhang, Shu-Yu

supporting information, p. 2823 - 2827 (2019/04/30)

A cascade [3 + 2] annulation and ring opening of N-aryloxyacetamides with 1-alkynylcyclobutanols via Rh(III)-catalyzed redox-neutral C-H/C-C activations using internal oxidative O-NHAc and -OH as the dual directing groups has been achieved. This reaction provided an efficient and regioselective approach to benzofuran derivatives with good functional group compatibility and high yields.

An internal oxidant-directing strategy enabling transition metal-free C–S bond ligation

Zuo, Yingying,Xiong, Feng,Zhao, Jing

supporting information, p. 4174 - 4179 (2019/05/24)

Organic sulfur compounds have broad applications in biology, medicine and material sciences and intensive efforts have been devoted to developing mild and general C–S bond-forming methods. However, a mild, transition-metal-free, direct C–H bond functionalization method remains elusive. Here, we report the use of an internal oxidant-directing strategy to achieve this goal. The cascade reactions described here show excellent chemoselectivity and a wide substrate scope for both oxyamines and sulfenylation reagents. This study enlarges the synthesis toolbox for preparing structurally diverse sulfilimines under mild conditions.

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