40485-33-4

Upstream product

• 40485-27-6 5-Methyl-1-phenylhex-2-in-1,5-diol 
• 590-37-4 2-methylpent-4-yn-2-ol 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 65007-63-8 C₁₆H₁₈O₃ 
• 16075-82-4 2,3-Dihydro-2,2-dimethyl-6-phenyl-4H-pyran-4-one 
• 133721-83-2 3-<2,2-Bis(phenylsulfonyl)ethyl>-2,3-dihydro-2,2-dimethyl-6-phenyl-4H-pyran-4-one 
• 133721-60-5 Methyl 2-benzoyl-5-<<(tert-butyl)dimethylsilyl>oxy>biphenyl-3-carboxylate 
• 133721-56-9 5-<(triisopropylsilyl)oxy>biphenyl-2-yl phenyl ketone 
• 133721-79-6 Methyl 2-benzoyl-5-methoxybiphenyl-3-carboxylate 
• 133721-70-7 Methyl 2-benzoyl-5-hydroxybiphenyl-3-carboxylate 
• 133721-55-8 5-<<(tert-Butyl)dimethylsilyl>oxy>biphenyl-2-yl phenyl ketone 
• 133721-72-9 6-Bromo-5-hydroxybiphenyl-2-yl phenyl ketone 
• 133721-67-2 5-Hydroxybiphenyl-2-yl phenyl ketone 
• 133721-49-0 5-Bromo-2,3-dihydro-2,2-dimethyl-6-phenyl-4H-pyran-4-one 
• 133721-54-7 4-Chloro-2,2-dimethyl-6-phenyl-2H-pyran 

Relevant academic research and scientific papers

A New General Synthesis of 2,2-Dialkyl-2,3-dihydro-4H-pyran-4-ones and Their Application for the in situ Preparation of Electron-Rich Dienes in Carbonyl-Alkyne Exchange Reactions with Acetylenes

The substituted 2,2-dialkyl-2,3-dihydro-4H-pyran-4-ones of type II and III have been prepared by acid-catalyzed cyclization of the corresponding substituted acetylenic ketones I in good to excellent yields (Scheme 1).These 2,2-dialkyl-2,3-dihydro-4H-pyran

53. Acid-Catalyzed Cyclization Rections of Substituted Acetylenic Ketones: A New Approach for the Synthesis of 3-Halofurans, Flavones, and Styrylchromones

Acetylenic acetals of type I (Scheme 1) and acetylenic ketones of type III (Scheme 1), 37 and 38 (Scheme 7) are versatile synthetic precursors for the synthesis of various heterocycles by acid-catalyzed cyclization reactions.By this way, substituted 3-halofurans of type II and IV (Scheme 1) and flavones and styrylchromones (Scheme 7) can be synthesized in good-to-excellent yields.The high degree of regioselectivity in the synthesis of the 3-halofurans (Scheme 4) is the result of the regioselective β-addition of HX (X = Cl, Br, I) to the acetylenic aldehyde and acetylenic ketone moieties.A possible mechanism is depicted in Scheme 5.Since 3-halofurans can easily be metalated and substituted, this approach constitutes a new synthesis of highly substituted furans.