404869-46-1Relevant academic research and scientific papers
DNA cleavage potency, cytotoxicity, and mechanism of action of a novel class of enediyne prodrugs
Dai, Wei-Min,Lai, Kwong Wah,Wu, Anxin,Hamaguchi, Wataru,Lee, Mavis Yuk Ha,Zhou, Ling,Ishii, Atsushi,Nishimoto, Sei-Ichi
, p. 758 - 761 (2007/10/03)
We have discovered a novel class of (E)-3-acyloxy-4-(arylmethylidene)cyclodeca-1,5-diynes which exhibit promising enediyne-like DNA cleavage and cytotoxic activities. LCMS analysis of the incubation mixture (pH 8.5, 37 °C) confirmed formation of 10-member
Enediyne derivatives
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, (2008/06/13)
Novel C3-substituted cyclodeca-1,5-diynes can be prepared through novel synthetic procedures using starting (E)-C3-substituted-4-(aryl- or heteroarylmethylidene)cyclodeca-1,5-diynes reagents. Both the C3-substituted cyclod
