359400-22-9

Upstream product

• 359400-20-7 (E)-10-Iodo-2-[(4'-methoxyphenyl)methylidene]deca-3,9-diynal 
• 123-11-5 4-methoxy-benzaldehyde 
• 359400-17-2 10-Iodo-2-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-deca-3,9-diyn-1-ol 
• 359400-14-9 2-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-deca-3,9-diynoic acid methyl ester 
• 57038-78-5 methyl 2-bromo-3-(4-methoxyphenyl)acrylate 
• 91089-40-6 2,3-dibromo-3-(4-methoxyphenyl)propionic acid methyl ester 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 

Downstream Products

• 404869-46-1 (E)-3-Acetoxy-4-[(4'-methoxyphenyl)methylidene]cyclodeca-1,5-diyne 
• 426207-05-8 (E)-3-Methoxyacetoxy-4-[(4'-methoxyphenyl)methylidene]cyclodeca-1,5-diyne 

Relevant academic research and scientific papers

DNA cleavage potency, cytotoxicity, and mechanism of action of a novel class of enediyne prodrugs

We have discovered a novel class of (E)-3-acyloxy-4-(arylmethylidene)cyclodeca-1,5-diynes which exhibit promising enediyne-like DNA cleavage and cytotoxic activities. LCMS analysis of the incubation mixture (pH 8.5, 37 °C) confirmed formation of 10-member

Enediyne derivatives

Novel C3-substituted cyclodeca-1,5-diynes can be prepared through novel synthetic procedures using starting (E)-C3-substituted-4-(aryl- or heteroarylmethylidene)cyclodeca-1,5-diynes reagents. Both the C3-substituted cyclod

Intramolecular Nozaki-Hiyama-Kishi reactions and Ln(III)-catalyzed allylic rearrangement as the key steps towards 10-membered ring enediynes

A general and facile synthesis of the 3-substituted 10-membered ring enediynes 18-22 from the aldehydes 8 and 15 has been established by utilizing the intramolecular Nozaki-Hiyama-Kishi reaction and the lanthanide(III)-catalyzed rearrangement of allylic alkoxyacetates as the key steps. This work provides ready access to the (E)-3-acyloxy-4-(arylmethylidene)cyclodeca-1,5-diynes, which can be converted into the bioactive enediynes under physiological conditions.