40491-00-7

Upstream product

• 55726-17-5 2,3,5-tri-O-benzyl-D-arabinose hydrazone 
• 160549-10-0 2,3,5-tri-O-benzyl-D-arabinofuranose 
• 89733-84-6 ethyl 1-(2,3,5-tri-O-benzyl-α-D-arabinofuranosyl)-1H-1,2,4-triazole-3-carboxylate 
• 52554-29-7 2,3,5-tri-O-benzyl-α- and β-D-arabinofuranosyl chlorides 
• 40372-08-5 methyl 1-trimethylsilyl-1,2,4-triazole-3-carboxylate 

Downstream Products

• 57198-01-3 1-(α-D-arabinofuranosyl)-1H-1,2,4-triazole-5-carboxamide 

Relevant academic research and scientific papers

1,2,4-Triazole nucleosides

As antiviral agents and intermediates therefor, 3-substituted 1-(β-D-glycosyl)-1,2,4-triazoles, O-acylated analogs thereof, and 5'- and 3',5'-cyclic phosphates of the triazole nucleosides, "glycosyl" being .[.a pentofuranosyl moiety, preferably one whose 2'-oxygen is trans to the triazole aglycon, e.g., xylofuranosyl,.]. ribofuranosyl, .[.2-0-methylribofuranosyl, etc.,.]. the triazole aglycon being 3-substituted with cyano, methylcarboxylate, carboxamidoxime, carboxamido-, thiocarboxamido, or carboxamidine. Preparation of these nucleosides is by silylation of the substituted triazole followed by glycosylation with the appropriate blocked glycosyl halide. Alternatively, acid-catalyzed fusion of the requisite 1,2,4-triazole with an O-acylated pentofuranose yields the nucleosides.