404919-14-8

Basic information

• Product Name: Benzenamine, 3,5-dimethyl-4-[(3-pentyl-1H-indazol-5-yl)oxy]-
• CAS NO: 404919-14-8
• Molecular Formula: C20H25N3O
• Molecular Weight: 323.438
• Mol File: 404919-14-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenamine, 3,5-dimethyl-4-[(3-pentyl-1H-indazol-5-yl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 3,5-dimethyl-4-[(3-pentyl-1H-indazol-5-yl)oxy]-(404919-14-8)
• EPA Substance Registry System: Benzenamine, 3,5-dimethyl-4-[(3-pentyl-1H-indazol-5-yl)oxy]-(404919-14-8)

Safety Data

• Hazardous Substances Data: 404919-14-8(Hazardous Substances Data)

Upstream product

• 404919-08-0 5-(2,6-dimethyl-4-nitrophenoxy)-3-pentyl-1H-indazole 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 58662-54-7 5-benzyloxy-2-nitrobenzaldehyde 
• 1736-85-2 2-fluoro-1,3-dimethyl-5-nitrobenzene 
• 404918-86-1 1-(5-benzyloxy-2-nitro-phenyl)-hex-2-yn-1-ol 
• 404919-00-2 1-(2-amino-5-hydroxyphenyl)-1-hexanone 
• 404919-04-6 5-hydroxy-3-pentyl-1H-indazole 

Downstream Products

• 404919-19-3 ethyl [5-(4-{bis[ethoxy(oxo)acetyl]amino}-2,6-dimethylphenoxy)-3-pentyl-1H-indazol-1-yl](oxo)acetate 

Relevant articles and documents

Novel heterocyclic thyromimetics

Novel heterocycle-fused thyromimetics are presented carrying indoles or indazoles instead of the phenolic group in T3. Potent agonists were identified in both series. SAR trends are examined and found to be mostly consistent with previously published thyromimetics. Moderate THRβ selectivity (approx. 10-fold) was observed in the indole series using isoform-selective transient THR transfection assays