404936-85-2

Upstream product

• 247158-79-8 5-Bromo-2-methoxymethyl-6-phenylpyridazin-3-one 
• 90766-97-5 5-bromo-6-phenylpyridazin-3(2H)-one 
• 247158-85-6 2-methoxymethyl-6-phenyl-5-(2-trimethylsilanylethynyl)-3-pyridazinone 

Relevant academic research and scientific papers

Pyridazine derivatives. Part 33: Sonogashira approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones

Several 6-phenyl-3(2H)-pyridazinones bearing different alkynyl groups at position 5 have been prepared by a palladium-catalysed Sonogashira cross-coupling reaction. An interesting base-promoted electronically permitted isomerization has been observed duri

Pyridazines. Part 25: Efficient and selective deprotection of pharmacologically useful 2-MOM-pyridazinones using Lewis acids

An efficient and selective procedure for the cleavage of a methoxymethyl group at the 2-position in acid-sensitive pyridazinones is presented. Deprotection with Lewis acids (boron tribromide or aluminium chloride) affords 3(2H)-pyridazinones under mild co