404953-16-8

Basic information

• Product Name: 2-Oxazolidinone, 3-[(2E)-3-(1,3-benzodioxol-5-yl)-1-oxo-2-propenyl]-4-(diphenylmethyl)-, (4R)-
• CAS NO: 404953-16-8
• Molecular Formula: C26H21NO5
• Molecular Weight: 427.456
• Mol File: 404953-16-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 3-[(2E)-3-(1,3-benzodioxol-5-yl)-1-oxo-2-propenyl]-4-(diphenylmethyl)-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 3-[(2E)-3-(1,3-benzodioxol-5-yl)-1-oxo-2-propenyl]-4-(diphenylmethyl)-, (4R)-(404953-16-8)
• EPA Substance Registry System: 2-Oxazolidinone, 3-[(2E)-3-(1,3-benzodioxol-5-yl)-1-oxo-2-propenyl]-4-(diphenylmethyl)-, (4R)-(404953-16-8)

Safety Data

• Hazardous Substances Data: 404953-16-8(Hazardous Substances Data)

Upstream product

• 96249-87-5 3-benzo[1,3]dioxol-5-yl-acryloyl chloride 
• 173604-33-6 (4R)-4-(diphenylmethyl)-2-oxazolidinone 

Downstream Products

• 404953-21-5 (4R)-4-(diphenylmethyl)-3-[3-(3,3-bis-3',4'-methylenedioxyphenyl)-propanoyl]-2-oxazolidinone 
• 404953-28-2 (3(2S),4R)-4-(diphenylmethyl)-3-[bis-(3',4'-methylenedioxyphenyl)-methyl]-(4-oxo-butyric acid tert-butyl ester)-2-oxazolidinone 

Relevant articles and documents

Enantioselective synthesis of peperomins A, C, D, and analogs - Examination of diastereoselective cuprate conjugate additions to N-enoyl-4-diphenylmethyl-2-oxazolidinones

A concise and general route to secolignans has been developed. The first total synthesis of secolignans peperomin A (1a), peperomin C (1b), and peperomin D (1c) was accomplished in ～28% overall yield over five synthetic steps. Peperomin analogs (1d) and (1e), possessing two differentially substituted aryl groups, were synthesized by a highly selective conjugate addition. The overall yield for the analogs 1d and 1e were 27 and 26%, respectively.