173604-33-6

Basic information

• Product Name: (R)-(+)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&
• Synonyms: (R)-(+)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&;(R)-4-Methyldiphenyl-2-oxazolidinone;(R)-4-Methyl-3,4-diphenyloxazolidin-2-one;(R)-4-Benzhydryloxazolidin-2-one
• CAS NO: 173604-33-6
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.3
• Product Categories: Asymmetric Synthesis;Chiral Auxiliaries;Oxazolidinone Derivatives
• Mol File: 173604-33-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 145-148 °C(lit.)
• Boiling Point: 472.603 °C at 760 mmHg
• Flash Point: 239.622 °C
• Appearance: /
• Density: 1.181 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: 2-8°C
• PKA: 12.29±0.40(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: (R)-(+)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&(173604-33-6)
• EPA Substance Registry System: (R)-(+)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN&(173604-33-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 173604-33-6(Hazardous Substances Data)

Usage

Uses

(R)-(+)-4-(Diphenylmethyl)-2-oxazolidinone is used as organic chemical synthesis intermediate.

InChI:InChI=1/C16H15NO2/c18-16-17-14(11-19-16)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,14-15H,11H2,(H,17,18)/t14-/m0/s1

Upstream product

• 312624-01-4 4-(diphenylmethyl)-2-oxazolidinone 
• 204851-65-0 (R)-2-Hydroxymethyl-3,3-diphenyl-propionic acid 
• 74262-56-9 (2R)-2-(tert-butyldimethylsilyloxy)propanal 
• 176839-76-2 4-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-oxo-butyric acid methyl ester 
• 87727-28-4 (S)-2-tert-butyl-dimethyl-silanyloxy propanal 
• 173604-32-5 (S)-4-(hydroxydiphenylmethyl)oxazolidin-2-one 

Downstream Products

• 183116-88-3 (R)-4-Benzhydryl-3-(7-methyl-octanoyl)-oxazolidin-2-one 
• 183116-89-4 (R)-4-Benzhydryl-3-hexadecanoyl-oxazolidin-2-one 
• 263716-56-9 (4R)-4-(diphenylmethyl)-3-[3-(ethoxypropanoyl)]-2-oxazolidinone 
• 263716-53-6 (4R)-4-(diphenylmethyl)-3-[3-(3'-methoxyphenyl)propanoyl]-2-oxazolidinone 
• 175272-35-2 (4R,2'S)-N-(α-bromopropionyl)-2-oxazolidinone 
• 175023-96-8 (4R,2'R)-N-(α-bromopropionyl)-2-oxazolidinone 
• 404953-16-8 (4R)-4-(diphenylmethyl)-3-[3-(3',4'-methylenedioxyphenyl)-2(E)-propenoyl]-2-oxazolidinone 
• 404953-12-4 (4R)-4-(diphenylmethyl)-3-[3-(3',4'-methylenedioxy-5'-methoxyphenyl)-2(E)-propenoyl]-2-oxazolidinone 
• 183116-86-1 (R)-4-Benzhydryl-3-hexanoyl-oxazolidin-2-one 
• 173604-34-7 (R)-4-Benzhydryl-2-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 
• 1417575-40-6 C₁₉H₁₉NO₃ 
• 1253413-37-4 C₂₄H₂₃NO₅ 
• 192823-98-6 (R)-4-Benzhydryl-3-{(2S,3S)-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-oxo-tetrahydro-furan-3-carbonyl}-oxazolidin-2-one 
• 192823-94-2 (R)-4-Benzhydryl-3-{(2R,3R)-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-oxo-tetrahydro-furan-3-carbonyl}-oxazolidin-2-one 

Relevant articles and documents

Synthesis and application of N-3,5-dinitrobenzoyl and C3 symmetric diastereomeric chiral stationary phases

Three diastereomeric chiral compounds, namely, (R,R)-(+)-2-amino-1,2-diphenylethanol, (1S,2R)-(+)-2-amino-1,2-diphenylethanol, and (1R,2R)-(+)-1,2-diphenylethylenediamine were used as starting materials for preparing three N-3,5-dinitrobenzoyl derivative

Preparation of chiral oxazolidin-2-ones and vicinal amino alcohols

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Synthesis of N-BOC-D-Diphenylalanine from L-Serine Methyl Ester Hydrochloride

A convenient six step synthesis of N-BOC-D-diphenylalanine from L-serine methyl ester hydrochloride is described.The preparation of a novel chiral auxiliary, an oxazolidinone derived from D-diphenylalaninol, is also described.