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(1S)-2-(4-CHLOROPHENYL)-1-METHYLETHYLAMINE, also known as 4-chloro-α-methylphenethylamine or 4-Cl-α-MePEA, is a synthetic organic compound with the molecular formula C9H12ClN. It is a chiral molecule, with the "1S" designation indicating the specific arrangement of atoms in the molecule. (1S)-2-(4-CHLOROPHENYL)-1-METHYLETHYLAMINE is structurally similar to amphetamine, featuring a phenyl ring with a chlorine atom at the 4-position and an α-methylethylamine side chain. It is used in scientific research and as a chemical intermediate, particularly in the synthesis of various pharmaceuticals and other organic compounds. Due to its structural resemblance to amphetamine, it is important to handle (1S)-2-(4-CHLOROPHENYL)-1-METHYLETHYLAMINE with care and in accordance with appropriate safety protocols.

405-46-9

405-46-9 Suppliers

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405-46-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 405-46-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 405-46:
(5*4)+(4*0)+(3*5)+(2*4)+(1*6)=49
49 % 10 = 9
So 405-46-9 is a valid CAS Registry Number.

405-46-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-(+)-1-(4'-chloro)phenyl-2-propanamine

1.2 Other means of identification

Product number -
Other names p-chloroamphetamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:405-46-9 SDS

405-46-9Relevant academic research and scientific papers

Asymmetric Synthesis of Chiral Halogenated Amines using Amine Transaminases

Dawood, Ayad W. H.,de Souza, Rodrigo O. M. A.,Bornscheuer, Uwe T.

, p. 951 - 955 (2018/02/12)

Amine transaminases (ATAs) are versatile and industrially relevant biocatalysts that catalyze the transfer of an amine group from a donor to an acceptor molecule. Asymmetric synthesis from a prochiral ketone is the most preferred route to the desired amine product, as it is obtainable in a theoretical yield of 100 %. In addition to the requirement of active and enantioselective ATAs, the choice of a suitable amine donor is also important to save costs and to avoid additional enzymes to shift the equilibrium and/or to recycle the cofactors. In this work, we identified suitable (R)- and (S)-ATAs from Aspergillus fumigatus and Silicibacter pomeroyi, respectively, to afford a set of halogen-substituted derivatives of brominated or chlorinated 1-phenyl-2-propanamine, 4-phenylbutan-2-amine, and 1-(3-pyridinyl)ethanamine. Optimization of the donor–acceptor ratio enabled application of isopropylamine as an amine donor, which resulted in high conversions and amines with 73–99 % ee.

Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

Munoz, Lourdes,Rodriguez, Anna M.,Rosell, Gloria,Bosch, M. Pilar,Guerrero, Angel

experimental part, p. 8171 - 8177 (2012/01/04)

Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used. The Royal Society of Chemistry 2011.