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N-OXIDE-2,4-DIMETHYL-3-PYRIDINE CARBOXYLIC ACID ETHYL ESTER is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

405058-67-5

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405058-67-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 405058-67-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,0,5 and 8 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 405058-67:
(8*4)+(7*0)+(6*5)+(5*0)+(4*5)+(3*8)+(2*6)+(1*7)=125
125 % 10 = 5
So 405058-67-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO3/c1-4-14-10(12)9-7(2)5-6-11(13)8(9)3/h5-6H,4H2,1-3H3

405058-67-5Relevant academic research and scientific papers

Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication

Skerlj, Renato,Bridger, Gary,Zhou, Yuanxi,Bourque, Elyse,McEachern, Ernest,Langille, Jonathan,Harwig, Curtis,Veale, Duane,Yang, Wen,Li, Tongshong,Zhu, Yongbao,Bey, Michael,Baird, Ian,Sartori, Michael,Metz, Markus,Mosi, Renee,Nelson, Kim,Bodart, Veronique,Wong, Rebecca,Fricker, Simon,Mac Farland, Ron,Huskens, Dana,Schols, Dominique

scheme or table, p. 6950 - 6954 (2012/01/13)

A series of CCR5 antagonists were optimized for potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells. Compounds that met acceptable ADME criteria, selectivity, human plasma protein binding, potency shift in the presence of α-glycoprotein were evaluated in rat and dog pharmacokinetics.

Chemokine receptor binding compounds

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Page/Page column 16, (2008/06/13)

The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds

CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS

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, (2008/06/13)

Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators.

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