405115-75-5Relevant academic research and scientific papers
Discovery and parallel synthesis of a new class of cathepsin K inhibitors
Smith, Roger A.,Bhargava, Ajay,Browe, Christopher,Chen, Jinshan,Dumas, Jacques,Hatoum-Mokdad, Holia,Romero, Romulo
, p. 2951 - 2954 (2007/10/03)
Peptidomimetic aminomethyl ketones have been identified as a new class of cathepsin K inhibitors. Traditional and high-speed parallel synthesis techniques were applied to investigate this series. Structure-activity relationships were established, and certain analogues were characterized with IC50 values in the range 200-500 nM.
