405174-48-3

Basic information

• Product Name: 4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI)
• Synonyms: 4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI);2,3-Dihydro-4H-pyrano[3,2-b]pyridin-4-one;2,3-Dihydropyrano[3,2-b]pyridin-4-one;2-b]pyridin-4-one;3-Dihydro-4H-pyrano[3;4H-Pyrano[3,2-b]pyridin-4-one;2H-pyrano[3,2-b]pyridin-4(3H)-one;2H-Pyrano[3,2-b]pyridin-4(3H)
• CAS NO: 405174-48-3
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.15
• Product Categories: PYRIDINE;API intermediates
• Mol File: 405174-48-3.mol

Chemical Properties

• Boiling Point: 305.709 °C at 760 mmHg
• Flash Point: 138.688 °C
• Appearance: /
• Density: 1.274 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: 2-8°C
• PKA: 2.49±0.20(Predicted)
• CAS DataBase Reference: 4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI)(405174-48-3)
• EPA Substance Registry System: 4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI)(405174-48-3)

Safety Data

• Hazardous Substances Data: 405174-48-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI) is used as a pharmaceutical agent for its potential anti-inflammatory properties, helping to reduce inflammation and alleviate pain in various conditions. Its analgesic effects make it a candidate for the development of pain-relief medications.
Used in Antiviral Applications:
In the field of antiviral research, 4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI) is utilized for its potential antiviral activity, which could be harnessed to develop treatments for viral infections. Its ability to inhibit viral replication and reduce the severity of viral diseases makes it a valuable compound in the search for new antiviral therapies.
Used in Drug Development:
4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI) is employed as a key component in drug development, where its unique structure and pharmacological properties are leveraged to create novel therapeutic agents. Its potential applications in various therapeutic areas, including inflammation, pain management, and antiviral treatments, make it an attractive target for medicinal chemists and pharmaceutical researchers.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI) serves as a valuable compound for studying the structure-activity relationships of heterocyclic compounds. Its pyrano-pyridone core structure provides a foundation for the design and synthesis of new molecules with improved pharmacological properties, enhancing the discovery of innovative therapeutic agents.

InChI:InChI=1/C8H7NO2/c10-6-3-5-11-7-2-1-4-9-8(6)7/h1-2,4H,3,5H2

Upstream product

• 405174-47-2 4-hydroxymethyl-3,4-dihydro-2H-pyrano[3,2-b]pyridinyl-4-ol 
• 6602-32-0 2-bromo-pyridin-3-ol 
• 405174-45-0 2-bromo-3-(but-3-en-1-yloxy)pyridine 
• 405174-46-1 4-methylene-3,4-dihydro-2H-pyrano[3,2-b]pyridine 

Downstream Products

• 754149-09-2 C₈H₉NO₂ 
• 1561765-29-4 (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxamide 
• 1561765-36-3 (S)-1-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-3-(6-fluoropyridin-3-yl)urea 2,2,2-trifluoroacetate 
• 1561765-64-7 (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate 
• 1561765-70-5 (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)pyridine-3-sulfonamide 2,2,2-trifluoroacetate 
• 1561778-47-9 (S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-amine hydrochloride 
• 1049634-21-0 Br^(1-)*C₃₅H₃₂N₂O₂P⁽¹⁺⁾ 
• 1049634-22-1 C₄₀H₃₄N₄O₂ 
• 1049634-23-2 C₃₈H₃₂N₄O 
• 1049634-20-9 C₁₇H₁₇BrN₂O₂ 
• 1561778-44-6 (S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide 
• 1561765-43-2 (S)-1-(4-cyanophenyl)-3-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)urea 
• 1561764-85-9 (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-5-hydroxypicolinamide 
• 1561763-62-9 (S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide 

Relevant articles and documents

6,7-dihydro-5H-quinoline-8-hydrazone derivative iron chelator and application in preparation of antitumor drug

The invention provides a 6,7-dihydro-5H-quinoline-8-hydrazone derivative iron chelator and its application in the preparation of an antitumor drug. Specifically, the invention provides a compound as shown in the formula I, wherein each substituent is as defined in the specification. The compound of the invention can be used as an inhibitor of tumor cell proliferation for the preparation of an antitumor drug.

HETEROCYCLIC THIOSEMICARBAZONE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS

Pharmaceutical compounds, compositions, and methods are presented in which various heterocyclic thiosemicarbazone derivatives are prepared. Contemplated compounds will be suitable to inhibit or reduce cellular growth or proliferation and are thus beneficial in the manufacture of drugs to treat neoplastic diseases.

CHROMAN DERIVATIVES AS TRPM8 INHIBITORS

Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

FUNCTIONALLY SELECTIVE AZANITRILE ALPHA2C ADRENORECEPTOR AGONISTS

In its many embodiments, the present invention provides a novel class of azanitrile compounds as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, method

DERIVATIVES AND ANALOGS OF CHROMAN AS FUNCTIONALLY SELECTIVE ALPHA2C ADRENORECEPTOR AGONISTS

In its many embodiments, the present invention provides a novel class of chroman compounds of formula I as α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of prepaxing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

CHEMICAL COMPOUNDS

There is provided novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as C

Chemokine receptor binding heterocyclic compounds with enhanced efficacy

The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).