405174-46-1

Basic information

• Product Name: 2H-Pyrano[3,2-b]pyridine,3,4-dihydro-4-methylene-(9CI)
• Synonyms: 2H-Pyrano[3,2-b]pyridine,3,4-dihydro-4-methylene-(9CI);4-Methylene-3,4-dihydro-2H-pyrano[3,2-b]pyridine;2-b]pyridine;2H-Pyrano[3;4-dihydro-4-Methylene-;3,4-Dihydro-4-Methylene-2H-Pyrano[3,2-b]Pyridine
• CAS NO: 405174-46-1
• Molecular Formula: C9H9NO
• Molecular Weight: 147.17
• Product Categories: PYRIDINE;API intermediates
• Mol File: 405174-46-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 260.77°C at 760 mmHg
• Flash Point: 95.486°C
• Appearance: /
• Density: 1.125g/cm³
• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• PKA: 4.31±0.20(Predicted)
• CAS DataBase Reference: 2H-Pyrano[3,2-b]pyridine,3,4-dihydro-4-methylene-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyrano[3,2-b]pyridine,3,4-dihydro-4-methylene-(9CI)(405174-46-1)
• EPA Substance Registry System: 2H-Pyrano[3,2-b]pyridine,3,4-dihydro-4-methylene-(9CI)(405174-46-1)

Safety Data

• Hazardous Substances Data: 405174-46-1(Hazardous Substances Data)

Usage

General Description

2H-Pyrano[3,2-b]pyridine, 3,4-dihydro-4-methylene-(9CI) is a chemical compound with a complex molecular structure. It is a bicyclic compound made up of a pyrano[3,2-b]pyridine ring system. The presence of the 4-methylene group in the molecule adds to its uniqueness and reactivity. This chemical may have potential applications in the pharmaceutical or agrochemical industries due to its structural features, which could potentially lend themselves to various biological activities. However, further research and study are necessary to fully understand the properties and potential uses of this compound.

InChI:InChI=1/C9H9NO/c1-7-4-6-11-8-3-2-5-10-9(7)8/h2-3,5H,1,4,6H2

Upstream product

• 6602-32-0 2-bromo-pyridin-3-ol 
• 405174-45-0 2-bromo-3-(but-3-en-1-yloxy)pyridine 
• 68696-18-4 tetraethylammonium chloride monohydrate 
• 627-27-0 homoalylic alcohol 
• 3375-31-3 palladium diacetate 

Downstream Products

• 405174-47-2 4-hydroxymethyl-3,4-dihydro-2H-pyrano[3,2-b]pyridinyl-4-ol 
• 1561765-29-4 (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxamide 
• 1561765-36-3 (S)-1-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-3-(6-fluoropyridin-3-yl)urea 2,2,2-trifluoroacetate 
• 1561765-64-7 (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate 
• 1561765-70-5 (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)pyridine-3-sulfonamide 2,2,2-trifluoroacetate 
• 405174-48-3 2,3-dihydro-4H-pyrano[3,2-b]pyridine-4-one 
• 1561778-47-9 (S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-amine hydrochloride 
• 1049634-21-0 Br^(1-)*C₃₅H₃₂N₂O₂P⁽¹⁺⁾ 
• 1049634-22-1 C₄₀H₃₄N₄O₂ 
• 1049634-23-2 C₃₈H₃₂N₄O 
• 1049634-20-9 C₁₇H₁₇BrN₂O₂ 
• 754149-09-2 C₈H₉NO₂ 
• 1561778-44-6 (S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide 
• 1561777-94-3 4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol 

Relevant articles and documents

6,7-dihydro-5H-quinoline-8-hydrazone derivative iron chelator and application in preparation of antitumor drug

The invention provides a 6,7-dihydro-5H-quinoline-8-hydrazone derivative iron chelator and its application in the preparation of an antitumor drug. Specifically, the invention provides a compound as shown in the formula I, wherein each substituent is as defined in the specification. The compound of the invention can be used as an inhibitor of tumor cell proliferation for the preparation of an antitumor drug.

CHROMAN DERIVATIVES AS TRPM8 INHIBITORS

Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

DERIVATIVES AND ANALOGS OF CHROMAN AS FUNCTIONALLY SELECTIVE ALPHA2C ADRENORECEPTOR AGONISTS

In its many embodiments, the present invention provides a novel class of chroman compounds of formula I as α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of prepaxing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.