405174-97-2

Basic information

• Product Name: 3-Bromo-2-pyridinecarboxaldehyde
• Synonyms: 3-Bromopyridine-2-carboxaldehyde;3-Bromo-2-pyridinecarboxaldehyde;3-Bromo-2-formylpyridine;3-Bromolpyridine-2-carboxaldehyde;3-Bromo-2-formylpyridine, 3-Bromopicolinaldehyde;3-BroMo-2-carboxaldehyde pyridine;3-bromopicolinaldehyde
• CAS NO: 405174-97-2
• Molecular Formula: C₆H₄BrNO
• Molecular Weight: 186.01
• Product Categories: pharmacetical;Aldehyde;Organohalides;Pyridine;Pyridines
• Mol File: 405174-97-2.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 222.989 °C at 760 mmHg
• Flash Point: 88.661 °C
• Appearance: /
• Density: 1.683 g/cm³
• Vapor Pressure: 0.099mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.12±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2-pyridinecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-pyridinecarboxaldehyde(405174-97-2)
• EPA Substance Registry System: 3-Bromo-2-pyridinecarboxaldehyde(405174-97-2)

Safety Data

• Hazardous Substances Data: 405174-97-2(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-pyridinecarboxaldehyde, also known as 3-bromo-2-pyridinecarboxaldehyde or 3-bromo-2-pyridylcarboxaldehyde, is a chemical compound with the molecular formula C6H4BrNO. It is a pale yellow to yellow crystalline powder that is used as a building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and fine chemicals. 3-Bromo-2-pyridinecarboxaldehyde is an important intermediate in the preparation of pyridine derivatives and is often used as a reagent in organic reactions due to its high reactivity. It is also commonly employed in the production of dyes and pigments. However, it should be handled and stored with care, as it is flammable and may cause skin and eye irritation upon contact.

InChI:InChI=1/C6H4BrNO/c7-5-2-1-3-8-6(5)4-9/h1-4H

Upstream product

• 626-55-1 3-Bromopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 30683-23-9 3-bromopicolinic acid 
• 13534-89-9 2,3-dibromopyridine 
• 867353-49-9 3-bromo-N-methoxy-N-methylpyridine-2-carboxamide 
• 38749-79-0 3-bromo-2-picoline 

Downstream Products

• 1318073-01-6 ethyl 3-(3-bromopyridin-2-yl)-5-methylisoxazole-4-carboxylate 
• 1383734-83-5 1-(3-bromopyridin-2-yl)ethanol 
• 1383735-22-5 C₁₂H₈FN₃O 
• 1383735-23-6 C₁₂H₈FN₃O 
• 1383735-24-7 C₁₂H₁₀FN₃O 
• 1383735-25-8 C₂₀H₁₈FN₃O₂ 
• 1383735-26-9 C₂₁H₂₀FN₃O₂ 
• 1383735-27-0 C₂₂H₂₂FN₃O₂ 
• 1383735-28-1 C₂₂H₂₄FN₃O 
• 1383735-63-4 1-(4-fluorophenyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine 
• 1383733-60-5 1-(4-fluorophenyl)-N-phenyl-1,5,6,7-tetrahydro-4H-pyrazolo[4,3-b]pyridine-4-carboxamide 
• 1383733-61-6 1-(4-fluorophenyl)-N-[3-(trifluoromethyl)benzyl]-1,5,6,7-tetrahydro-4H-pyrazolo[4,3-b]pyridine-4-carboxamide 
• 1383733-62-7 1-(4-fluorophenyl)-1,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid [(S)-1-(6-bromo-pyridin-3-yl)-propyl]-amide 
• 1383733-63-8 1-(4-fluorophenyl)-1,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid 4-(tetrahydro-pyran-4-ylsulfamoyl)-benzylamide 

Relevant articles and documents

Design, synthesis and characterization of HIV-1 ca-targeting small molecules: Conformational restriction of PF74

Small molecules targeting the PF74 binding site of the HIV-1 capsid protein (CA) confer potent and mechanistically unique antiviral activities. Structural modifications of PF74 could further the understanding of ligand binding modes, diversify ligand chemical classes, and allow identification of new variants with balanced antiviral activity and metabolic stability. In the current work, we designed and synthesized three series of PF74-like analogs featuring conformational constraints at the aniline terminus or the phenylalanine carboxamide moiety, and characterized them using a biophysical thermal shift assay (TSA), cell-based antiviral and cytotoxicity assays, and in vitro metabolic stability assays in human and mouse liver microsomes. These studies showed that the two series with the phenylalanine carboxamide moiety replaced by a pyridine or imidazole ring can provide viable hits. Subsequent SAR identified an improved analog 15 which effectively inhibited HIV-1 (EC50 = 0.31 μM), strongly stabilized CA hexamer (?Tm = 8.7?C), and exhibited substantially enhanced metabolic stability (t1/2 = 27 min for 15 vs. 0.7 min for PF74). Metabolic profiles from the microsomal stability assay also indicate that blocking the C5 position of the indole ring could lead to increased resistance to oxidative metabolism.

HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF

The present invention relates to a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the treatment of various HAT-related diseases or conditions.

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.