405201-32-3

Upstream product

• 7217-59-6 2-Methoxybenzenethiol 
• 492471-02-0 2-(3,4-difluoro-phenyl)-7-methoxy-3-p-tolyl-benzo[b]thiophene 
• 492470-97-0 2-(3,4-difluoro-phenyl)-2-(2-methoxy-phenylsulfanyl)-1-p-tolyl-ethanone 

Downstream Products

• 492471-14-4 1-[2-(3,4-difluoro-phenyl)-7-hydroxy-3-p-tolyl-benzo[b]thiophen-6-yl]-ethanone 

Relevant academic research and scientific papers

A facile synthesis of 7,8-di aryl coumarino and flavano benzo-thiophenes

The key step for the synthesis of 7-hydroxy 2,3-diarylsubstituted benzothiophenes 5a-f, by starting from substituted 2-aryl-2-((2-methoxy phenyl)thio)acetophenones 3a-f as an intermediate, consists of a Friedel-Crafts cyclization followed by demethylation by Lewis acids like BF3OEt2 and AlCl3 in DCM.

Facile synthesis of substituted 4-hydroxy coumarinobenzothiophenes

The Lewis acid in dichloromethane mediated cyclization and demethylation of substituted 2-aryl-2-((2-methoxy phenvl)thio)acetophenones 3a-f at room temperature converting into 7-hydroxy-2,3-diaryl substituted benzothiophenes 4a-f.These were condenced with substituted malonic acids by the same reagent to produce the substituted 4-hydroxy coumarino benzothiophenes (6a-f & 7a-f).