405230-91-3

Usage

Uses

Used in Pharmaceutical Industry:
2,5-dichloro-3-nitropyridin-4-amine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,5-dichloro-3-nitropyridin-4-amine serves as an intermediate in the production of agrochemicals, potentially enhancing crop protection and yield through the development of novel pesticides and other related compounds.
Used in Dye Industry:
2,5-dichloro-3-nitropyridin-4-amine is utilized as an intermediate in the manufacture of dyes, contributing to the creation of a diverse range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Organic Compounds Synthesis:
As a versatile intermediate, 2,5-dichloro-3-nitropyridin-4-amine is employed in the synthesis of other organic compounds, expanding the scope of chemical research and development in various industries.

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 405230-82-2 2,5-dichloro-4-amino-pyridine 
• 405230-87-7 2,5-dichloro-4-nitraminopyridine 
• 405230-81-1 2,5-dichloro-4-nitropyridine-1-oxide 
• 53976-62-8 2,5-dichloro-1-oxido-pyridin-1-ium 

Downstream Products

• 405230-94-6 3,4-diamino-2,5-dichloropyridine 
• 405231-09-6 4,7-dichloro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 163152-53-2 3-chloro-3-deazaadenosine 

Relevant academic research and scientific papers

Novel nucleosides and related processes, pharmaceutical compositions and methods

The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention include novel 2 halogen-substituted, 3 halogen-substituted, and 2′,3′dihalogen-substituted analogues of 3-deazaadenosine, and novel 3 halogen-substituted analogues of 3-deazaguanosine. Compounds of the instant invention, including 4-Amino-6-fluoro-1-(β-D-ribofuranosyl)imidazo[4,5-c]pyridine and 6-Amino-7-bromo-1,5-dihydro-1-β-D-ribofuranosylimidazo[4,5-c]pyridin-4-one, have exhibited potent antiviral and anticancer activity in vitro. The compounds are also useful in the concomitant treatment of bacterial infections associated with viral infections such as AIDS.

Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents

Various 2-halogen-substituted analogues (38, 39, 43 and 44), 3-halogensubstituted analogues (51 and 52), and 2′,3′ -dihalogen- substituted analogues (57-60) of 3-deazaadenosine and 3-halogen-substituted analogues (61 and 62) of 3-deazaguanosine have been synthesized as potential anticancer and/or antiviral agents. Among these compounds, 3-deaza-3-bromoguanosine (62) showed significant cytotoxicity against L1210, P388, CCRF-CEM and B16F10 cell lines in vitro, producing IC50 values of 3, 7, 9 and 7μM, respectively. Several 3-deazaadenosine analogues (38, 51, 57 and 59) showed moderate to weak activity against hepatitis B virus.