405230-93-5

Usage

Uses

Used in Antifungal Applications:
2-Chloro-5-fluoro-3,4-pyridinediamine is used as an antifungal agent for the treatment of onychomycosis, a fungal infection of the nails. It is effective in inhibiting protein synthesis in fungi, which results in the death of the fungal cells and the resolution of the infection.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Chloro-5-fluoro-3,4-pyridinediamine is used as a key component in the formulation of topical solutions for the treatment of fungal infections. Its effectiveness in treating onychomycosis and other dermatophyte infections makes it a valuable addition to the arsenal of antifungal medications.
Used in Topical Solutions:
2-Chloro-5-fluoro-3,4-pyridinediamine is used in the form of a topical solution for the direct application to the affected area, providing a targeted treatment for fungal infections. This form of application allows for localized action, reducing the risk of systemic side effects and enhancing the overall safety and tolerability of the treatment.
Used in Treatment of Various Fungal Infections:
2-Chloro-5-fluoro-3,4-pyridinediamine is used as a broad-spectrum antifungal agent for the treatment of various types of fungal infections, including those caused by dermatophytes. Its potent antifungal activity makes it suitable for addressing a wide range of fungal infections, offering a versatile treatment option for patients suffering from these conditions.
Overall, 2-Chloro-5-fluoro-3,4-pyridinediamine, or Tavaborole, is a significant compound in the field of antifungal therapy, offering effective treatment options for patients with onychomycosis and other fungal infections. Its targeted action, low risk of adverse effects, and broad-spectrum activity make it a valuable asset in the pharmaceutical industry and a preferred choice for healthcare professionals and patients alike.

Upstream product

• 405230-90-2 4-amino-2-chloro-5-fluoro-3-nitropyridine 
• 31301-51-6 2-chloro-5-fluoropyridine 
• 405230-79-7 2-chloro-5-fluoropyridine-1-oxide 
• 89510-90-7 4-amino-2-chloro-5-fluoropyridine 
• 405230-86-6 2-chloro-5-fluoro-4-nitraminopyridine 
• 405230-80-0 2-chloro-5-fluoro-4-nitropyridine-1-oxide 

Downstream Products

• 405230-97-9 4-chloro-7-fluoro-1H-imidazo[4,5-c]pyridine 
• 405231-23-4 1-[(1-acetyloxy-1-ethoxy)methyl]-4-chloro-7-fluoroimidazo[4,5-c]pyridine 
• 202806-40-4 3-deaza-3-fluoro-adenosine 
• 405231-08-5 4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 1334411-84-5 4-chloro-7-fluoro-2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridine 
• 1334407-22-5 2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine 
• 1334407-23-6 N-(2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-yl)cyclopropanecarboxamide 
• 1334411-83-4 4-bromo-2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridine 

Relevant academic research and scientific papers

IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

The invention provides compounds of Formulas Ia-Ib, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R4, R5 and R16 are defined herein, a pharmaceutical composition that includes a compound of Formulas Ia-Ib and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of using the compound or composition in therapy.

Novel nucleosides and related processes, pharmaceutical compositions and methods

The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention include novel 2 halogen-substituted, 3 halogen-substituted, and 2′,3′dihalogen-substituted analogues of 3-deazaadenosine, and novel 3 halogen-substituted analogues of 3-deazaguanosine. Compounds of the instant invention, including 4-Amino-6-fluoro-1-(β-D-ribofuranosyl)imidazo[4,5-c]pyridine and 6-Amino-7-bromo-1,5-dihydro-1-β-D-ribofuranosylimidazo[4,5-c]pyridin-4-one, have exhibited potent antiviral and anticancer activity in vitro. The compounds are also useful in the concomitant treatment of bacterial infections associated with viral infections such as AIDS.

Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents

Various 2-halogen-substituted analogues (38, 39, 43 and 44), 3-halogensubstituted analogues (51 and 52), and 2′,3′ -dihalogen- substituted analogues (57-60) of 3-deazaadenosine and 3-halogen-substituted analogues (61 and 62) of 3-deazaguanosine have been synthesized as potential anticancer and/or antiviral agents. Among these compounds, 3-deaza-3-bromoguanosine (62) showed significant cytotoxicity against L1210, P388, CCRF-CEM and B16F10 cell lines in vitro, producing IC50 values of 3, 7, 9 and 7μM, respectively. Several 3-deazaadenosine analogues (38, 51, 57 and 59) showed moderate to weak activity against hepatitis B virus.