40531-93-9

Upstream product

• 758-16-7 N,N-dimethylthioformamide 
• 121-98-2 methyl 4-methoxybenzoate 
• 124-40-3 dimethyl amine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 16208-17-6 2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one 
• 46318-58-5 4-methoxybenzoylnitromethane 
• 68-12-2 N,N-dimethyl-formamide 
• 18096-70-3 3-(dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one 

Downstream Products

• 185851-68-7 2-(4-methoxyphenyl)-N,N-dimethyl-2-thioethane-thioamide 

Relevant academic research and scientific papers

Efficient Synthesis of α-Ketothioamides From α-Nitroketones, Amines or DMF and Elemental Sulfur Under Oxidant-Free Conditions

We have developed a practical, general protocol for denitration of readily available α-nitroketones with sulfur and amines to access a broad range of α-ketothioamides under mild conditions. Such a reaction proceeds under metal-, oxidant-, and catalyst-free conditions to provide synthetically useful α-ketothioamides. Furthermore, the mild reaction conditions tolerate a wide range of substrates especially for the synthesis of aliphatic α-ketothioamides which are rarely reported.

Synthesis of α-Keto Thioamides by Metal-Free C-C Bond Cleavage in Enaminones Using Elemental Sulfur

An unprecedented method for cleaving the C-C bond in N,N-disubstituted enaminones in the presence of elemental sulfur and N,N-dimethyl-4-aminopyridine is disclosed. Without using any metal catalyst or additive, the cascade functionalization of both C?C an

Na2S-mediated thionation: An efficient access to secondary and tertiary α-ketothioamides via Willgerodt-Kindler reaction of readily available arylglyoxals with amines

The task of this paper is to provide an efficient process for synthesis of secondary and tertiary α-ketothioamides via Willgerodt-Kindler reaction of readily available arylglyoxals with amines using Na2S as an effective catalyst. A plausible role for Na2S in the reaction of arylglyoxals with primary amines is proposed.

Summary - α-Thioxothioamides : [4 + 2] cycloaddition reactions with dimethyl acetylenedicarboxylate and methyl propiolate

The title compounds are prepared from methyl ketones through a three-step reaction: chloration with thionyl chloride; amination of the resulting α-chloro-β-oxosulfenyl chlorides; and thionation of α-oxothioamides with Lawesson's reagent. Two competitive h