405506-91-4Relevant academic research and scientific papers
Bio-inspired polyene cyclization: Synthesis of tetracyclic terpenoids promoted by steroidal acetal-SnCl4
Zhao, Yu-Jun,Loh, Teck-Peng
, p. 1434 - 1436 (2008/12/23)
This communication describes a highly efficient intermolecular polyene cyclization method using steroidal acetals as the initiators to synthesize tetracyclic terpenoids; both good yields and good asymmetric induction were obtained. The Royal Society of Chemistry.
Regioselective palladium-catalyzed alkylation of allylic halides with benzylic Grignard reagents. Two-step synthesis of abietane terpenes and tetracyclic polyprenoid compounds
Rosales, Viale,Zambrano, Jorge L.,Demuth, Martin
, p. 1167 - 1170 (2007/10/03)
A highly regioselective palladium-catalyzed α-alkylation of allylic bromides 1a,c-e and chloride 1b with substituted and unsubstituted benzylic Grignard reagents is reported. The resulting alltrans polyenehomobenzene derivatives were obtained in excellent yields and regioselectivity. These products were easily converted to abietane-type diterpenes (10-12) and tetracyclic polyprenoid compounds (13, 14) through a Lewis acid-promoted cascade polyene cyclization reaction.
