405554-63-4 Usage
Yellow crystalline substance
This describes the physical appearance of the compound, which is a yellow solid with a crystalline structure.
Building block in synthesis
1H-Indene-5-carboxaldehyde, 2,3-dihydro-1-(methoxyimino)is used as an intermediate in the synthesis of other organic compounds, including pharmaceuticals, fragrances, and other chemicals.
Aromatic odor
This refers to the smell of the compound, which is typically associated with aromatic hydrocarbons and is characterized as pleasant or sweet.
Flavoring agent in food industry
The compound is used as a flavoring agent in the food industry, likely due to its aromatic odor.
Production of dyes and pigments
1H-Indene-5-carboxaldehyde, 2,3-dihydro-1-(methoxyimino)is also used in the production of dyes and pigments, which are industrial chemicals used to color fabrics, plastics, and other materials.
Antimicrobial and antioxidant properties
The compound has potential applications in the field of medicine due to its antimicrobial and antioxidant properties, which are being studied further. Antimicrobial properties refer to the ability to kill or inhibit the growth of microorganisms, while antioxidant properties refer to the ability to prevent or reduce damage to cells caused by oxidative stress.
Check Digit Verification of cas no
The CAS Registry Mumber 405554-63-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,5,5 and 4 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 405554-63:
(8*4)+(7*0)+(6*5)+(5*5)+(4*5)+(3*4)+(2*6)+(1*3)=134
134 % 10 = 4
So 405554-63-4 is a valid CAS Registry Number.
405554-63-4Relevant articles and documents
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds
Niculescu-Duvaz, Dan,Niculescu-Duvaz, Ion,Suijkerbuijk, Bart M.J.M.,Ménard, Delphine,Zambon, Alfonso,Nourry, Arnaud,Davies, Lawrence,Manne, Helen A.,Friedlos, Frank,Ogilvie, Lesley,Hedley, Douglas,Takle, Andrew K.,Wilson, David M.,Pons, Jean-Francois,Coulter, Tom,Kirk, Ruth,Cantarino, Neus,Whittaker, Steven,Marais, Richard,Springer, Caroline J.
experimental part, p. 6934 - 6952 (2010/11/03)
V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) is a serine/threonine-specific protein kinase that is mutated with high frequency in cutaneous melanoma, and many other cancers. Inhibition of mutant BRAF is an attractive therapeutic approach for the treatment of melanoma. A triarylimidazole BRAF inhibitor bearing a phenylpyrazole group (dimethyl-[2-(4-{5-[4-(1H-pyrazol-3-yl)-phenyl]-4-pyridin-4-yl-1H-imidazol-2-yl} -phenoxy)-ethyl]-amine, 1a) was identified as an active BRAF inhibitor. Based on this starting point, we synthesized a series of analogues leading to the discovery of 6-{2-[4-(4-methyl-piperazin-1-yl)-phenyl]-5-pyridin-4-yl-3H- imidazol-4-yl}-2,4-dihydro-indeno[1,2-c]pyrazole (1j), with nanomolar activity in three assays: inhibition of purified mutant BRAF activity in vitro; inhibition of oncogenic BRAF-driven extracellular regulated kinase (ERK) activation in BRAF mutant melanoma cell lines; and inhibition of proliferation in these cells.
