405554-66-7

Usage

Uses

Used in Chemical Research:
1,2-Ethanedione, 1-[2,3-dihydro-1-(MethoxyiMino)-1H-inden-5-yl]-2-(4-pyridinyl)is used as a research compound for exploring its chemical properties and reactivity in various chemical reactions and processes.
Used in Pharmaceutical Research:
1,2-Ethanedione, 1-[2,3-dihydro-1-(MethoxyiMino)-1H-inden-5-yl]-2-(4-pyridinyl)is used as a pharmaceutical research compound for investigating its potential biological activities and medicinal properties, which may contribute to the development of new drugs and therapies.
Used in Drug Design and Development:
1,2-Ethanedione, 1-[2,3-dihydro-1-(MethoxyiMino)-1H-inden-5-yl]-2-(4-pyridinyl)is used as a key component in drug design and development, leveraging its unique structure and properties to create novel therapeutic agents with potential applications in various medical fields.
Used in the Study of Biochemical Pathways and Processes:
1,2-Ethanedione, 1-[2,3-dihydro-1-(MethoxyiMino)-1H-inden-5-yl]-2-(4-pyridinyl)is used as a tool in the study of various biochemical pathways and processes, providing insights into the mechanisms of action and potential interactions with biological targets.
Note: The specific applications and uses of 1,2-Ethanedione, 1-[2,3-dihydro-1-(MethoxyiMino)-1H-inden-5-yl]-2-(4-pyridinyl)would need to be further investigated through scientific research and experimentation to fully understand its potential and limitations in various fields.

Upstream product

• 34598-49-7 5-Bromo-1-indanone 
• 405554-64-5 5-(1,2-dihydroxy-2-(pyridin-4-yl)-ethyl)-indan-1-one O-methyloxime 
• 405554-65-6 5-[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-2-pyridin-4-yl-ethyl]-indan-1-one O-methyl-oxime 
• 405554-62-3 5-bromo-2,3-dihydro-1H-inden-1-one O-methyl oxime 
• 405554-63-4 1-(methoxyimino)-2,3-dihydro-1H-indene-5-carbaldehyde 

Downstream Products

• 1251931-49-3 5-{2-[2-(4-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)]}-1H-inden-1-one O-methyloxime 
• 405554-85-0 5-{2-[4-(2-dimethylaminoethoxy)-phenyl]-5-(pyridin-4-yl)-1H-imidazol-4-yl}-indan-1-one O-methyloxime 

Relevant academic research and scientific papers

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds

V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) is a serine/threonine-specific protein kinase that is mutated with high frequency in cutaneous melanoma, and many other cancers. Inhibition of mutant BRAF is an attractive therapeutic approach for the treatment of melanoma. A triarylimidazole BRAF inhibitor bearing a phenylpyrazole group (dimethyl-[2-(4-{5-[4-(1H-pyrazol-3-yl)-phenyl]-4-pyridin-4-yl-1H-imidazol-2-yl} -phenoxy)-ethyl]-amine, 1a) was identified as an active BRAF inhibitor. Based on this starting point, we synthesized a series of analogues leading to the discovery of 6-{2-[4-(4-methyl-piperazin-1-yl)-phenyl]-5-pyridin-4-yl-3H- imidazol-4-yl}-2,4-dihydro-indeno[1,2-c]pyrazole (1j), with nanomolar activity in three assays: inhibition of purified mutant BRAF activity in vitro; inhibition of oncogenic BRAF-driven extracellular regulated kinase (ERK) activation in BRAF mutant melanoma cell lines; and inhibition of proliferation in these cells.

The identification of potent and selective imidazole-based inhibitors of B-Raf kinase

A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase.