40569-51-5Relevant academic research and scientific papers
Strain-driven direct cross-aldol and -ketol reactions of four-membered heterocyclic ketones
Dobi, Zoltán,Holczbauer, Tamás,Soós, Tibor
, p. 2634 - 2637 (2015)
Owing to the ring strain and α-heteroatom effect, the four-membered heterocyclic ketones can undergo direct cross-aldol and -ketol reactions without the need for preformed enol or "enolate-like" intermediates. Besides the organocatalyzed cross-ketol addition onto their highly active carbonyl group, their ability to act as a nucleophilic donor has also been explored. As a result, a number of discrete aldol adducts were synthesized and the distinct reactivities were successfully combined into a double-aldol one-pot reaction.
