40586-20-7Relevant academic research and scientific papers
Preparation method of alpha-acyloxy ketone compound
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Paragraph 0028-0030, (2021/08/06)
The invention discloses a preparation method of an alpha-acyloxy ketone compound, which comprises the following steps of adding a 1, 3-dicarbonyl compound, carboxylate and a catalyst alkyl halide into an organic solvent, and stirring and reacting for 0.5-1 hour at the temperature of 20-30 DEG C to obtain a reaction product, namely a mixture, performing purification treatment on the mixture to obtain alpha-acyloxy ketone, wherein the molar ratio of the 1, 3-dicarbonyl compound to the carboxylate to the alkyl halide is 1: 1: 1. According to the method, carboxylate with low cost is selected as an acyloxylation reagent, reaction conditions are mild and green, a 1, 3-dicarbonyl compound is taken as a raw material, and a novel method for efficiently, simply and conveniently constructing a C-O bond is successfully realized through activation of a carbonyl alpha-position C-H bond and subsequent cascade reaction, so that a series of alpha-acyloxyketone compounds are obtained.
