405931-45-5

Usage

Chemical structure

1-(1-bromoethyl)-3-fluorobenzene is composed of a benzene ring with a fluorine atom and a bromoethyl group attached to it.

Physical state

It is a colorless liquid.

Molecular weight

197.06 g/mol

Applications

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Building block in organic synthesis
d. Production of specialty chemicals

Hazardous nature

1-(1-bromoethyl)-3-fluorobenzene is considered a hazardous chemical.

Safety precautions

It should be handled with care, following proper safety precautions and guidelines.

Upstream product

• 350-51-6 3-fluorostyrene 
• 402-63-1 1-(3-fluorophenyl)ethanol 

Relevant academic research and scientific papers

Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γagonists/Soluble Epoxide Hydrolase Inhibitors

Polypharmaceutical regimens often impair treatment of patients with metabolic syndrome (MetS), a complex disease cluster, including obesity, hypertension, heart disease, and type II diabetes. Simultaneous targeting of soluble epoxide hydrolase (sEH) and p

Thiourea-Mediated Halogenation of Alcohols

The halogenation of alcohols under mild conditions expedited by the presence of substoichiometric amounts of thiourea additives is presented. The amount of thiourea added dictates the pathway of the reaction, which may diverge from the desired halogenation reaction toward oxidation of the alcohol, in the absence of thiourea, or toward starting material recovery when excess thiourea is used. Both bromination and chlorination were highly efficient for primary, secondary, tertiary, and benzyl alcohols and tolerate a broad range of functional groups. Detailed electron paramagnetic resonance (EPR) studies, isotopic labeling, and other control experiments suggest a radical-based mechanism. The fact that the reaction is carried out at ambient conditions, uses ubiquitous and inexpensive reagents, boasts a wide scope, and can be made highly atom economic, makes this new methodology a very appealing option for this archetypical organic reaction.

SMALL MOLECULE INHIBITORS OF ALDH AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.

Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins

To improve access to a key synthetic intermediate we targeted a direct hydrobromination-Negishi route. Unsurprisingly, the anti-Markovnikov addition of HBr to estragole in the presence of AIBN proved successful. However, even in the absence of an added initiator, anti-Markovnikov addition was observed. Re-examination of early reports revealed that selective Markovnikov addition, often simply termed "normal" addition, is not always observed with HBr unless air is excluded, leading to the rediscovery of a reproducible and scalable initiator-free protocol.

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (I) wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

2″-deoxy hygromycin derivatives

This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1and R2are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1.

Studies in Nucleophilic Substitutions: Part I - Reactions between Phenylmethylcarbinols and Hydrobromic Acid and Structure-Reactivity Analysis

The kinetics of the reactions of phenylmethylcarbinol (PMC) and substituted PMCs with hydrobromic acid have been studied in 100percent acetic acid.The reaction rate follows total second order, first order each in and .The effect of substituents in the phenyl ring on the rate of substitution has been studied.The analysis of the rate data in terms of the Hammett equation gives a concave-down type of curve, though the Exner plot is linear.A stepwise mechanism involving the equilibrium formation of the conjugate acid of the alcohol followed by an attack by Br(-) accounts for the observed structure-reactivity pattern.