40598-79-6

Upstream product

• 55558-81-1 4-(4-methylphenyl)-2,4-dioxobutanoic acid 
• 95-54-5 1,2-diamino-benzene 
• 1407513-26-1 2-chloro-3-(p-tolylethynyl)quinoxaline 
• 2213-63-0 2,3-dichloroquinoxaline 
• 766-97-2 4-n-methylphenylacetylene 
• 924-44-7 glyoxylic acid ethyl ester 

Relevant academic research and scientific papers

Cu(OTf)2 loaded protonated trititanate nanotubes catalyzed reaction: A facile method for the synthesis of furo[2,3-: B] quinoxalines

An efficient method is developed for the synthesis of furo[2,3-b]quinoxalines using novel Cu(OTf)2 loaded protonated trititanate nanotube catalysts via A3-coupling followed by 5-endo-dig cyclization from o-phenylenediamines, ethylglyoxalate and phenylacetylenes. This method is beneficial and advantageous as it facilitates high yield in conventional heating and a short reaction time besides offering reusable heterogeneous catalysts. These catalysts can be recovered by centrifugation and their activity remain largely unchanged for five successive runs. On the other side, these catalysts are prepared using simple hydrothermal and wet-impregnation methods and are characterized using XRD, HR-TEM and N2-adsorption-desorption techniques.

Trifluoroacetic Acid Mediated One-Pot Synthesis of Furo-Fused Quinoxalines/Pyrazines

A trifluoroacetic acid promoted step-economical one-pot approach to the synthesis of furo-fused quinoxalines/pyrazines by the reaction of 2,3-dichloroquinoxalines/pyrazines with alkynes is described. The reaction involves a selective in-situ Sonogashira c

Copper(II) catalyzed expeditious synthesis of furoquinoxalines through a one-pot three-component coupling strategy

Microwave assisted one-pot transformation has been developed for the synthesis of biologically significant polysubstituted furoquinoxalines in good to excellent yields through a copper(II) catalyzed three-component coupling of o-phenylenediamine, ethylglyoxalate, and terminal alkyne, known as A3-coupling, followed by 5-endo-dig cyclization.

Transition metal free hydrolysis/cyclization strategy in a single pot: Synthesis of fused furo N-heterocycles of pharmacological interest

A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single pot leading to fused furo N-heterocycles as potential inhibitors of sirtuins. A representative compound showed promising pharmacological properties in vitro and in vivo.