40598-81-0

Upstream product

• 60943-28-4 3-[2-(4-methoxyphenyl)-2-oxoethyl]quinoxalin-2(1H)-one 
• 108-24-7 acetic anhydride 
• 60943-28-4 3-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-1H-quinoxalin-2-one 
• 1448-87-9 2-chloroquinoxaline 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 55558-77-5 4-(4-methoxyphenyl)-2,4-dioxobutanoic acid 
• 924-44-7 glyoxylic acid ethyl ester 
• 95-54-5 1,2-diamino-benzene 
• 768-60-5 4-methoxyphenylacetylen 

Relevant academic research and scientific papers

Synthesis of [2,3-b]thieno- and furoquinoxalines by the SN H and SNipso reactions of 2-substituted quinoxalines with acetophenones

The treatment of quinoxalin-2-one with acetophenones in the presence of boron trifluoride gives 3-(2-hydroxy-2-R-vinyl)-quinoxalin-2-ones, which can be transformed into [2,3-b]thienoquinoxalines by reactions with P2S 5.

Cu(OTf)2 loaded protonated trititanate nanotubes catalyzed reaction: A facile method for the synthesis of furo[2,3-: B] quinoxalines

An efficient method is developed for the synthesis of furo[2,3-b]quinoxalines using novel Cu(OTf)2 loaded protonated trititanate nanotube catalysts via A3-coupling followed by 5-endo-dig cyclization from o-phenylenediamines, ethylglyoxalate and phenylacetylenes. This method is beneficial and advantageous as it facilitates high yield in conventional heating and a short reaction time besides offering reusable heterogeneous catalysts. These catalysts can be recovered by centrifugation and their activity remain largely unchanged for five successive runs. On the other side, these catalysts are prepared using simple hydrothermal and wet-impregnation methods and are characterized using XRD, HR-TEM and N2-adsorption-desorption techniques.

Copper(II) catalyzed expeditious synthesis of furoquinoxalines through a one-pot three-component coupling strategy

Microwave assisted one-pot transformation has been developed for the synthesis of biologically significant polysubstituted furoquinoxalines in good to excellent yields through a copper(II) catalyzed three-component coupling of o-phenylenediamine, ethylglyoxalate, and terminal alkyne, known as A3-coupling, followed by 5-endo-dig cyclization.