406-40-6Relevant articles and documents
Synthesis of Trifluoromethyl-allenes by Gold-Catalyzed Rearrangement of Propargyl Benzyl Ethers
Boreux, Arnaud,Lonca, Geoffroy H.,Riant, Olivier,Gagosz, Fabien
supporting information, p. 5162 - 5165 (2016/10/14)
A new method for the synthesis of trifluoromethyl-allenes from easily accessible α-trifluoromethyl-propargyl benzyl ether derivatives following a gold-catalyzed intramolecular hydride transfer has been developed. Various di- and trisubstituted trifluoromethyl-allenes were obtained in good to excellent yields.
Trifluoromethylation of Aliphatic Halogen Compounds
Bouillon, Jean-Philippe,Maliverney, Christian,Merenyi, Robert,Viehe, Heinz G.
, p. 2147 - 2149 (2007/10/02)
Aryl, heteroaryl or vinyl halides can be trifluoromethylated using CF3CO2Na-CuI.With alkyl iodides, however, the method fails, yielding trifluoroacetyl esters instead.Allylic halogens can be substituted with Burton's reagent, obtained from dihalogenodifluoromethane via CF3CdHal and transmetallation with CuI.A new access to trifluoropropionic acid is thereby found.Prop-2-ynyl bromide produces trifluormethylallene.Attempts at trifluoromethylation of bromoacetate with CF3CO2Na-CuI in NMP (N-methyl-2-pyrrolidone) solution led to formation of the trifluoroacetoxy derivative and of a formal adduct of hexafluoroacetone to the α position of NMP.