40600-90-6 Usage
Description
D-HIS-PROTIRELIN, also known as 5-Oxo-L-prolyl-D-histidyl-L-prolinamide, is a synthetic peptide that serves as a crucial component in the synthesis of thyrotropin-releasing hormone (TRH) analogs. These analogs are known for their central nervous system (CNS) activity and their role in regulating the release of thyroid-stimulating hormone (TSH). D-HIS-PROTIRELIN is characterized by its unique structure and functional properties, making it a valuable compound in the field of pharmaceuticals and neuroscience.
Uses
Used in Pharmaceutical Industry:
D-HIS-PROTIRELIN is used as an intermediate in the solid phase or solution synthesis of TRH peptides. These peptides are known for their TSH-releasing hormone activity, which is essential for maintaining proper thyroid function and overall metabolic regulation. D-HIS-PROTIRELIN plays a vital role in the development of new therapeutic agents targeting the endocrine system and related disorders.
Used in Neuroscience Research:
In addition to its pharmaceutical applications, D-HIS-PROTIRELIN is also utilized in neuroscience research. It serves as a valuable tool for studying the mechanisms of TRH and its analogs in the central nervous system. This research can lead to a better understanding of the role of TRH in various physiological processes and the development of novel treatments for neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 40600-90-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,6,0 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 40600-90:
(7*4)+(6*0)+(5*6)+(4*0)+(3*0)+(2*9)+(1*0)=76
76 % 10 = 6
So 40600-90-6 is a valid CAS Registry Number.
40600-90-6Relevant articles and documents
A SIMPLE METHOD FOR SYNTHESIS OF AMIDES AND PEPTIDES THROUGH ACYL CHLORIDES. A RAPID SYNTHESIS OF THYROTROPIN RELEASING HORMONE
Matsuda, Fuyuhiko,Itoh, Shin,Hattori, Noritaka,Yanagiya, Mitsutoshi,Matsumoto, Takeshi
, p. 3625 - 3631 (2007/10/02)
By improvement of the classical SOCl2-pyridine method for the preparation of acid chlorides, amides and optically pure peptides were synthesized rapidly in a simple manner from DCHA (dicyclohexylammonium) salts of carboxylic acids.This modified SOCl2-pyridine method was applied to a rapid synthesis of TRH.
