40601-45-4

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 25411-73-8 diethyl diazomethylphosphonate 
• 352276-27-8 1-iodo-4-phenylbutan-2-one 
• 122-52-1 triethyl phosphite 
• 10419-77-9 diethyl iodomethanephosphonate 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 2550-26-7 4-Phenyl-2-butanone 
• 31984-10-8 1-bromo-4-phenylbutan-2-one 
• 768-56-9 4-Phenylbut-1-ene 
• 762-04-9 phosphonic acid diethyl ester 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 1217357-13-5 2-(hydroxymethyl)-5-phenylpent-1-en-3-one 
• 55076-60-3 (3aR,4R,5R,6aS)-2-oxo-4-((1E)-3-oxo-5-phenylpent-1-en-1-yl)-hexahydro-2H-cyclopenta[b]furan-5-yl benzoate 
• 55444-68-3 (3aR,4R,5R,6aS)-4-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]-2-oxo-hexahydro-2H-cyclopenta[b]furan-5-yl benzoate 
• 41639-74-1 (3aR,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-5-phenyl-3-hydroxy-(1E)-pentenyl]-2H-cyclopentane [β] furan-2-one 
• 856240-62-5 (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]-2H-cyclopenta[b]furan-2,5-diol 
• 155206-00-1 bimatoprost 
• 82102-19-0 2-amino-4-phenylbutylphosphonic acid 
• 2550-26-7 4-Phenyl-2-butanone 

Relevant academic research and scientific papers

Manganese-catalyzed oxophosphorylation reaction of carbon–carbon double bonds using molecular oxygen in air

A novel aerobic manganese-catalyzed oxophosphorylation reaction of carbon–carbon double bonds of styrene derivatives and vinyl ethers using diethyl H-phosphonates was developed. This direct transformation of alkenes to β-ketophosphonate readily proceeded at room temperature via the direct incorporation of molecular oxygen present in air (open flask).

Mn(OAc)3-Promoted Oxidative Csp3-P Bond Formation through Csp2-Csp2 and P-H Bond Cleavage: Access to β-Ketophosphonates

The Mn(OAc)3-promoted oxidative phosphonylation of N,N-dimethylenaminones with H-phosphonates, involving a chemo- and regioselective Csp2-Csp2 bond cleavage and Csp3-P bond formation in one step, provided successfully functionalized β-ketophosphonates under mild reaction conditions. Oxidative Csp3-H/P-H cross-coupling reactions via Csp3-C(C=O) bond cleavage and mechanistic studies are conducted preliminarily, and a possible mechanism is proposed. This novel method proceeds in good to excellent yields, shows operational simplicity, broad substrate scope, and large-scale preparation.

Novel method for preparing Prostaglandin derivatives

Provided is a novel method for preparing prostaglandin derivatives. The method is suitable for mass production by effectively manufacturing prostaglandin derivatives with high yield. The method comprises the following steps: (S-1) adding a first reducing agent to a prostaglandin intermediate compound represented by chemical formula II and manufacturing a compound represented by chemical formula III; (S-2) manufacturing a compound represented by chemical formula IV from the compound represented by chemical formula III in the presence of a base; (S-3) adding a second reducing agent to the compound represented by chemical formula IV and manufacturing a compound represented by chemical formula V; and (S-4) performing Wittig reaction of the compound represented by chemical formula V and a compound represented by chemical formula VI, and manufacturing a compound represented by chemical formula I.COPYRIGHT KIPO 2017

Novel cobalt(0)- or magnesium-mediated approaches to β-ketophosphonates

Two novel approaches to β-ketophosphonates, based on cobalt(0)- or magnesium-mediated reactions of α-halophosphonates with esters are described.

Preparation of 1-aminoalkylphosphonic acids and 2-aminoalkylphosphonic acids by reductive amination of oxoalkylphosphonates

By reacting dialkyl 1-oxo- or 2-oxoalkylphosphonates with benzhydrylamine followed by reduction with triacetoxyborohydride and acid hydrolysis gave corresponding aminoalkylphosphonic acids with satisfactory yields. The use of benzylamine, α-methylbenzylamine and tritylamine was unsuccessful in the case of dialkyl 1-oxoalkylphosphonates whereas conversion of 2-oxoalkylphosphonates was also achieved although with lower yields.

TIN(II) CHLORIDE CATALYZED ADDITION OF DIAZO SULFONES, DIAZO PHOSPHINE OXIDES, AND DIAZO PHOSPHONATES TO ALDEHYDES.

Diazo sulfones, diazo phosphine oxides, and diazo phosphonates add to aldehydes in the presence of a catalytic amounts of tin(II) chloride to yield β-keto sulfones, β-keto phosphine oxides, and β-keto phosphonates, respectively.Reactions with primary aldehydes proceed in higher yields, 53-79percent, than those of secondary aldehydes, 42-56percent.Reactions with tertiary aldehydes, which are more sterically encumbered substrates, give only 5-36percent yields. KEY WORDS: Tin(II) chloride, catalyst, β-keto sulfones, β-keto phosphine oxides, and β-keto phosphonates.