82102-19-0Relevant academic research and scientific papers
Preparation of 1-aminoalkylphosphonic acids and 2-aminoalkylphosphonic acids by reductive amination of oxoalkylphosphonates
Ryglowski, Artur,Kafarski, Pawel
, p. 10685 - 10692 (2007/10/03)
By reacting dialkyl 1-oxo- or 2-oxoalkylphosphonates with benzhydrylamine followed by reduction with triacetoxyborohydride and acid hydrolysis gave corresponding aminoalkylphosphonic acids with satisfactory yields. The use of benzylamine, α-methylbenzylamine and tritylamine was unsuccessful in the case of dialkyl 1-oxoalkylphosphonates whereas conversion of 2-oxoalkylphosphonates was also achieved although with lower yields.
PREPARATION OF OPTICALLY ACTIVE 2-AMINOALKYLPHOSPHINIC AND PHOSPHONIC ACIDS
Duggan, Mark E.,Karanewsky, Donald S.
, p. 2935 - 2938 (2007/10/02)
The reaction of sodium alkylphosphinates or sodium dialkylphosphonates with tosylamino tosylates of amino alcohols derived from 1-aminoalkylcarboxylic acids gives high yields of optically active 2-tosylaminoalkylphosphinic or phosphonic esters.
ANIMATION REDUCTRICE DES β-CETOPHOSPHONATES: PREPARATION D'ACIDES AMINOALKYLPHOSPHONIQUES
Varlet, J. M.,Collignon, N.,Savignac, Ph.
, p. 3713 - 3721 (2007/10/02)
Diethyl 2-oxo-alkylphosphonates undergo reductive amination in the presence of an amine and sodium cyanohydridoborate (NaBH3CN) in MeOH at Ph 7-7.5.Studies with a large variety of ketophosphonates show that the reaction rate is very sensitive to steric hi
