40615-02-9

Basic information

• Product Name: (+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
• Synonyms: (+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE;3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DIHYDROCHLORIDE;(-3-Amino-1,2,3,4-tetrahydroquinoline2HCl;()-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE 2HC;3-QuinolinaMine, 1,2,3,4-tetrahydro-;1,2,3,4-Tetrahydroquinolin-3-aMine;1,2,3,4-Tetrahydro-3-quinolinamine
• CAS NO: 40615-02-9
• Molecular Formula: C₉H₁₂N₂
• Molecular Weight: 148.2
• Product Categories: pharmacetical
• Mol File: 40615-02-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 354.4°Cat760mmHg
• Flash Point: 168.2°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.34E-05mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: (+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE(40615-02-9)
• EPA Substance Registry System: (+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE(40615-02-9)

Safety Data

• Hazardous Substances Data: 40615-02-9(Hazardous Substances Data)

Usage

Uses

1,2,3,4-Tetrahydroquinolin-3-amine is used in the preparation of state-dependant NaV1.7 inhibitors for the treatment of neuropathic pain.

InChI:InChI=1/C9H12N2.2ClH/c10-8-5-7-3-1-2-4-9(7)11-6-8;;/h1-4,8,11H,5-6,10H2;2*1H

Upstream product

• 580-17-6 3-aminoquinoline 

Downstream Products

• 1609340-85-3 rac-8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-(1,2,3,4-tetrahydroquinolin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide 

Relevant articles and documents

Cu-Catalyzed Chemoselective Reduction of N-Heteroaromatics with NH3·BH3 in Aqueous Solution

An efficient catalytic system was successfully developed on reduction of N-heteroaromatics with H3N?BH3 as hydrogen source in CuSO4 solution, featuring excellent chemoselectivity as well as very broad functional group tolerance. Various challenging substrates, such as OH-, NH2-, Cl-, Br-, etc., contained quinolines, quinoxalines, 1,5-naphthyridines and quinazolines were all reduced smoothly. Mechanistic studies suggested that [Cu-H] intermediate might be generated from NH3?BH3, which was believed to form with H3N?BH3 in CuSO4 solution.

2,9-DIAMINO- AND 2-AMINO-8-CARBAMOYL-4-HYDROXY-ALKANOIC ACID AMIDE DERIVATIVES

Compounds of the formula I STR1 in which R 1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a carbonyl or methylene group, R 2 and R 3 independently of one another are hydrogen or lower alkyl or, together with the carbon atom with which they are bonded, are a cycloalkylidene radical, R 4 is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl, R 5 is hydroxyl, lower alkanoyloxy or lower alkoxycarbonyloxy, R 6 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl-lower alkyl, aryl-lower alkyl or heteroaryl-lower alkyl having 5 to 7 ring atoms in the heteroaryl ring and R 7 is hydrogen or lower alkyl, or R 6 and R. sub.7, together with the carbon atom with which they are bonded, are a cydoalkylidene radical and R 8 denotes an aliphatic, cycloaliphatic-aliphatic or heteroarylaliphatic radical, and their salts can be used as active ingredients for medicaments for treatment of high blood pressure.