40620-62-0

Basic information

• Product Name: 3-hydroxy-3-(4-fluorophenyl)propanoic acid
• Synonyms: 3-hydroxy-3-(4-fluorophenyl)propanoic acid
• CAS NO: 40620-62-0
• Molecular Weight: 184.167
• Mol File: 40620-62-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-(4-fluorophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-(4-fluorophenyl)propanoic acid(40620-62-0)
• EPA Substance Registry System: 3-hydroxy-3-(4-fluorophenyl)propanoic acid(40620-62-0)

Safety Data

• Hazardous Substances Data: 40620-62-0(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 64-19-7 acetic acid 
• 2754-27-0 trimethylsilyl acetate 
• 136568-65-5 (RS)-3-(4-fluorophenyl)-3-hydroxypropionitrile 

Relevant articles and documents

Homoserine lactone derivatives, preparation method thereof and pharmaceutical composition for prevention or treatment of the periodontal diseases containing the same as an active ingredient

The present invention relates to homoserine lactone derivatives, optical isomers of the same, or pharmaceutically acceptable salts of the same. The homoserine lactone derivatives in the present invention have excellent properties as a quorum sensing antagonist which hinders communications among bacteria. According to the present invention, the homoserine lactone derivatives can hinder gene expressions of bacteria while effectively blocking formation of biofilm which is known to raise resistance against antibiotics, and suppress propagation of bacteria, thereby being useful as a pharmaceutical composition for preventing or treating periodontal diseases.

Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented β-hydroxy functionality enhanced amide formation

To explore the synthetic potential of nitrilase ZmNIT2 from maize, the substrate specificity of this nitrilase was studied with a diverse collection of nitriles. The nitrilase ZmNIT2 showed high activity for all the tested nitriles except benzonitrile, producing both acids and amides. For the hydrolysis of aliphatic, aromatic nitriles, phenylacetonitrile derivatives and dinitriles, carboxylic acids were the major products. Unexpectedly, amides were found to be the major products in nitrilase ZmNIT2-catalyzed hydrolysis of β-hydroxy nitriles. The hydrogen bonding between the hydroxyl group and nitrogen in the enzyme-substrate complex intermediates that disfavors the loss of ammonia and formation of acyl-enzyme intermediate, which was further hydrolyzed to acid, was proposed to be responsible for the unprecedented β-hydroxy functionality assisted high yield of amide formation.