406213-94-3Relevant articles and documents
Soluble alpha-amino acid salts in acetonitrile: practical technology for the production of some dipeptides.
Palomo, Claudio,Palomo, Antonio L,Palomo, Francisco,Mielgo, Antonia
, p. 4005 - 4008 (2007/10/03)
Alpha-amino acids are soluble in acetonitrile when treated with phosphazene bases. As a result, the protection/deprotection events that are usually required for peptide coupling reactions can be minimized. This is illustrated in the synthesis of the important angiotensin-converting enzyme (ACE) inhibitor enalapril. [reaction: see text]