40622-01-3Relevant academic research and scientific papers
Synthesis and characterization of photoactive columnar liquid crystals containing azobenzene and quinoxaline moieties
Cristiano, Rodrigo,Gallardo, Hugo,Girotto, Edivandro,Silva, Welisson P.
, (2020/03/30)
In this study, we report the synthesis and characterization of thermal and optical properties of photoactive molecules containing both quinoxaline and azobenzene moieties. Two series of molecules in which the quinoxaline is connected to the azobenzene wit
Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors
You, Lei,Cho, Eun Jeong,Leavitt, John,Ma, Li-Chung,Montelione, Gaetano T.,Anslyn, Eric V.,Krug, Robert M.,Ellington, Andrew,Robertus, Jon D.
supporting information; experimental part, p. 3007 - 3011 (2011/06/24)
A library of quinoxaline derivatives were prepared to target non-structural protein 1 of influenza A (NS1A) as a means to develop anti-influenza drug leads. An in vitro fluorescence polarization assay demonstrated that these compounds disrupted the dsRNA-NS1A interaction to varying extents. Changes of substituent at positions 2, 3 and 6 on the quinoxaline ring led to variance in responses. The most active compounds (35 and 44) had IC50 values in the range of low micromolar concentration without exhibiting significant dsRNA intercalation. Compound 44 was able to inhibit influenza A/Udorn/72 virus growth.
Methods of treating conditions associated with an Edg-7 receptor
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, (2008/06/13)
In one aspect, the present invention provides a method for modulating an Edg-7 receptor mediated biological activity in a cell. A cell expressing the Edg-7 receptor is contacted with a modulator of the Edg-7 receptor which is capable of modulating an Edg-7 receptor mediated biological activity. In another aspect, the present invention provides a method for modulating an Edg-7 receptor mediated biological activity in a subject. A therapeutically effective amount of a modulator of the Edg-7 receptor is administered to the subject.
Methods of treating conditions associated with an Edg-7 receptor
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, (2008/06/13)
In one aspect, the present invention provides a method for modulating an Edg-7 receptor mediated biological activity in a cell. A cell expressing the Edg-7 receptor is contacted with a modulator of the Edg-7 receptor which is capable of modulating an Edg-7 receptor mediated biological activity. In another aspect, the present invention provides a method for modulating an Edg-7 receptor mediated biological activity in a subject. A therapeutically effective amount of a modulator of the Edg-7 receptor is administered to the subject.
Bis-(ortho-aminophenol)-carboxylic acid AB2 monomer
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, (2008/06/13)
An AB2monomer of the formula: wherein Z is selected from the group consisting of —OH, —SH and —NH2HCl, is useful for the preparation of hyperbranched polybenzoxazoles.
Room-temperature free-radical-induced polymerization of 1,1′-(methylenedi-1,4-phenylene)bismaleimide via a novel diphenylquinoxaline-containing hyperbranched aromatic polyamide
Baek, Jong-Beom,Ferguson, John B.,Tan, Loon-Seng
, p. 4385 - 4396 (2007/10/03)
Two new diphenylquinoxaline-containing AB2 monomers, 2,3-bis(4-aminophenyl)quinoxaline-6-carboxylic acid, 5 and 2,3-bis[4-(4-aminophenoxy)phenyl]quinoxaline-6-carboxylic acid, 9 were prepared and polymerized via the Yamazaki reaction to form th
Quinoxaline-containing AB2 monomers for hyperbranched aromatic polyamides
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, (2008/06/13)
AB2monomers of the formula wherein Q is Polymerization of these monomers results in hyperbranched aromatic polyamides.
