406225-74-9Relevant academic research and scientific papers
Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues
Hindley, Stephen,Ward, Stephen A.,Storr, Richard C.,Searle, Natalie L.,Bray, Patrick G.,Park, B. Kevin,Davies, Jill,O'Neill, Paul M.
, p. 1052 - 1063 (2007/10/03)
The potent antimalarial activity of chloroquine against chloroquine-sensitive strains can be attributed, in part, to its high accumulation in the acidic environment of the heme-rich parasite food vacuole. A key component of this intraparasitic chloroquine
