40627-30-3

Usage

Uses

Used in Pharmaceutical Research and Development:
7-Deaza-2,3-dideoxyadenosine Suppliers is used as a research compound for the development of antiviral and antitumor drugs. Its ability to inhibit RNA synthesis makes it a promising candidate for the treatment of various viral infections, including HIV and herpes.
Used in Scientific Studies:
7-Deaza-2,3-dideoxyadenosine Suppliers is used as a research tool in scientific studies to investigate the mechanisms of viral infections and the development of resistance to antiviral drugs. It helps researchers understand the molecular interactions between the compound and viral enzymes, providing insights into the design of more effective antiviral therapies.
Used in Drug Formulation:
7-Deaza-2,3-dideoxyadenosine Suppliers is used in the formulation of antiviral and antitumor drugs. Pharmaceutical companies utilize the compound as an active ingredient in the development of new medications, leveraging its antiviral and antitumor properties to create effective treatments for various diseases.
Used in Quality Control and Standardization:
7-Deaza-2,3-dideoxyadenosine Suppliers is used as a reference standard in the quality control and standardization of antiviral and antitumor drugs. It serves as a benchmark for assessing the purity, potency, and efficacy of these medications, ensuring their safety and effectiveness for patients.
Used in Educational Institutions:
7-Deaza-2,3-dideoxyadenosine Suppliers is used as an educational tool in academic institutions, particularly in the fields of chemistry, biochemistry, and pharmacology. It provides students and researchers with a practical example of a nucleoside analog and its applications in drug development and antiviral research.
Used in Diagnostics and Therapeutic Monitoring:
7-Deaza-2,3-dideoxyadenosine Suppliers is used in the development of diagnostic tests and therapeutic monitoring tools for viral infections and cancer. 7-Deaza-2,3-dideoxyadenosine Suppliers can be incorporated into assays and other analytical methods to detect the presence of specific viruses or to monitor the response of patients to antiviral or antitumor treatments.

InChI:InChI=1/C11H14N4O2/c12-10-8-3-4-15(11(8)14-6-13-10)9-2-1-7(5-16)17-9/h3-4,6-7,9,16H,1-2,5H2,(H2,12,13,14)/t7-,9+/m0/s1

Upstream product

• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 69-33-0 tubercidin 
• 115899-25-7 2-Acetoxy-2-methyl-propionic acid (2R,3S,4S,5R)-4-acetoxy-5-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3-bromo-tetrahydro-furan-2-ylmethyl ester 
• 40725-89-1 4-amino-N7-(3'-deoxy-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 
• 128878-82-0 4-amino-7-<3-deoxy-5-O-4-methoxytrityl-2-O-phenoxy(thiocarbonyl)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 128878-76-2 4-amino-7-<3-deoxy-5-O-(4-methoxytrityl)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 119447-94-8 4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine 
• 119447-93-7 4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo<2,3-d>pyrimidine 
• 119447-95-9 4-Chloro-7-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo<2,3-d>pyrimidine 
• 91713-43-8 4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 97337-37-6 4-chloro-7-<2-deoxy-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>-pyrimidine 
• 64702-16-5 7-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 135885-06-2 7-{(2R,5S)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine 

Downstream Products

• 114748-69-5 C₁₄H₂₀N₅O₁₁P₃ 
• 114748-71-9 7-deaza-2',3'-dideoxy-7-(3-trifluoroacetamidopropyn-1-yl)adenosine 
• 114748-70-8 7-deaza-2',3'-dideoxy-7-iodoadenosine 
• 135093-00-4 Phosphoric acid mono-[(2S,5R)-5-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-2-ylmethyl] ester; compound with triethyl-amine 
• 135092-96-5 C₁₁H₁₇N₄O₁₁P₃*4C₆H₁₅N 

Relevant academic research and scientific papers

NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF PARASITIC INFECTIONS

The present invention relates to novel nucleoside analogues and compositions containing said nucleoside analogues. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the diagnosis, prevention and/or treatment of parasitic infections, more specifically for use in the diagnosis, prevention and/or treatment of a Trypanosoma infection.

Synthesis of 2',3'-didehydro-2',3'-didoxyformycin A, 2',3'-Dideoxyformycin A and 2',3'-Dideoxytubercidin

2',3'-Didehydro-2',3'-dideoxyformycin A (7) was prepared by reaction of the 7-amino-3-[5-O-(2-acetoxyisobutyryl)-3-bromo-3-deoxy-2-O- phenoxy(thiocarbonyl)-β-D-xylofuranosyl]-1 H-pyrazolo [4,3-d]-pyrimidine (5) or 7-amino-3-[5-O-(2-acetoxyisobutyryl)-2- bromo-2-deoxy-3-O-phenoxy(thiocarbonyl)-β-D-arabinofuranosyl]-1 H-pyrazolo[4,3-d]pyrimidine (9) with tributyltin hydride and subsequent deprotection of the resulting 5'-O-(2-acetoxyisobutyryl)-2',3'-didehydro-2',3'-dideoxyformycin A (6). 2',3'-Dideoxyformycin A (13) and 2',3'-dideoxytubercidin (16) were synthesized via deoxygeneration of their respective 3'-deoxy counterparts 10 and 2, respectively.