40725-89-1 Usage
Description
3'-Deoxytubercidin is a synthetic nucleoside analogue that is a modified form of adenosine, with the hydroxyl group at the 3' position of the sugar ring replaced by a hydrogen atom. This modification makes the compound resistant to degradation by adenosine deaminase, an enzyme that breaks down adenosine in the body. It has been studied for its potential anti-cancer, anti-viral activities, and its ability to inhibit RNA synthesis.
Uses
Used in Pharmaceutical Industry:
3'-Deoxytubercidin is used as a potential anti-cancer agent for its potential to inhibit RNA synthesis and its resistance to degradation by adenosine deaminase. It is also being studied for its potential anti-viral activities.
Used in Autoimmune and Inflammatory Conditions:
3'-Deoxytubercidin is used as a potential drug for the treatment of autoimmune diseases and inflammatory conditions due to its ability to inhibit RNA synthesis and its resistance to degradation by adenosine deaminase.
However, more research is needed to fully understand the therapeutic potential and mechanisms of action of this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 40725-89-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,7,2 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 40725-89:
(7*4)+(6*0)+(5*7)+(4*2)+(3*5)+(2*8)+(1*9)=111
111 % 10 = 1
So 40725-89-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H14N4O3/c12-9-7-1-2-15(10(7)14-5-13-9)11-8(17)3-6(4-16)18-11/h1-2,5-6,8,11,16-17H,3-4H2,(H2,12,13,14)/t6-,8+,11+/m0/s1
40725-89-1Relevant articles and documents
-
Robins et al.
, p. 4074,4075 (1973)
-
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
-
, (2008/06/13)
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.