40631-01-4

Upstream product

• 364356-55-8 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-phosphoroselenoate 
• 145498-72-2 5'-O-(4,4'-dimethoxytrityl)-thymidine-3'-O-(2-seleno-1,3,2-oxathiaphospholane) 
• 21090-30-2 3'-O-acetylthymidine 
• 88819-27-6 C₅₂H₅₁ClN₅O₁₅P 

Relevant academic research and scientific papers

Solution phase synthesis of dithymidine phosphorodithioate using new S- protecting groups in combination with a chemoselective coupling reagent (PyNOP)

A method for the synthesis of O-thymidin-3'-yl S-alkyl dithiophosphate monomers 1 with different S-protecting groups has been developed. These have been used for solution phase synthesis of dithymidine phosphorodithioate by a new phosphotriester method. C

Dithymidylyl-3',5'-phosphorofluoridates: New Synthesis and Stability under Solvolytic Conditions

Dithymidylyl-3',5'-phosphorofluoridates, prepared by nucleophilic substitution of methylselenyl by fluoride ion, are relatively unstable under solvolytic conditions and undergo rapid base-catalysed hydrolysis/methanolysis.

SPECIFIC REMOVAL OF 5-CHLORO-8-QUINOLYL PROTECTING GROUP OF INTERNUCLEOTIDIC BONDS

5-Chloro-8-quinolyl protecting group of internucleotidic bonds was efficiently removed by treatment with zinc acetate or 2-pyridine-carboxaldehyde oxime at room temperature.On the other hand, alkaline hydrolysis of phosphotriester intermediates with free