40639-93-8Relevant academic research and scientific papers
Thio acid-mediated conversion of azides to amides – Investigation of 2-azidotetrahydobenzimidazoles and derivatives
Seal, Lawton A.,Ojo, Olatunji S.,Gout, Delphine,Lovely, Carl J.
, (2020/10/14)
An investigation of the thio acid-azide coupling reaction to afford amides is reported employing 2-azidotetrahydrobenzimidazoles and the corresponding spiro fused 2-azidoimidazolones. The tetrahydrobenzimidazole derivatives react as expected to produce th
JAK-2 MODULATORS AND METHODS OF USE
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Page/Page column 215-216, (2008/06/13)
This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention
A Simple and Practical Synthesis of 2-Aminoimidazoles
Little, Thomas L.,Webber, Stephen E.
, p. 7299 - 7305 (2007/10/02)
A new and simple two-step procedure to synthesize 2-aminoimidazoles (2-AI's) from readily available materials has been developed.The cyclization reaction of α-halo ketones and N-acetylguanidine in acetonitrile (MeCN) at reflux, or in dimethylformamide (DMF) at ambient temperature, gives 4(5)-substituted and 4,5-disubstituted N-(1H-imidazol-2-yl)acetamides, which are then hydrolyzed to their respective 2-AI's.In general, the purified products were isolated in good yields.We have prepared several examples and have demonstrated the usefulness of this method by its application in the total synthesis of 8, an interesting histamine analog, and oroidin, 15, a marine natural product isolated from various sponges.
