40650-90-6Relevant academic research and scientific papers
Chelate oxorhenium to assemble new integrin antagonists
Le Gal, Julien,Gonera, Marta,Lelait, Marie-Anne,Servent, Denis,Dugave, Christophe
body text, p. 880 - 886 (2012/03/26)
Assembly of independent chemical modules through oxorhenium coordination by a NS2 + S chelation motif was applied to the synthesis of RGD (Arg-Gly-Asp) analogs. Modules were assembled through oxorhenium chelation to give a series of 18 metal complexes in good yields and satisfactory purities. Screening of these oxorhenium coordinates as antagonists of integrins αVβ3, αIIbβ3 and αVβ5 led to the identification of 3 bioactive compounds that exhibit submicromolar affinities for the 3 integrins. Preliminary studies showed that the corresponding oxotechnetium complexes are stable in mice plasma and therefore could be proposed for the molecular imaging of pathologies that overexpress integrins αVβ3 and αVβ5.
