406502-76-9

Upstream product

• 6346-15-2 dimethyl α-chloromethylphosphonate 
• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 

Downstream Products

• 406502-80-5 dimethyl (2S,3R)-(-)-3-phenylaziridine-2-phosphonate 
• 406502-83-8 dimethyl (2R)-(+)-2-phenyl-2H-azirine 3-phosphonate 

Relevant academic research and scientific papers

Asymmetric synthesis of aziridine 2-phosphonates from enantiopure sulfinimines (N-sulfinyl imines). Synthesis of α-amino phosphonates

An aza-Darzens reaction, involving the addition of chloromethylphosphonate anions to enantiopure sulfinimines, has been developed for the asymmetric synthesis of aziridine 2-phosphonates. Best results involve cyclization of the syn and anti diastereomeric

2H-Azirine 3-phosphonates: a new class of chiral iminodienophiles. Asymmetric synthesis of quaternary piperidine phosphonates.

[reaction: see text] Diels-Alder reactions of enantiomerically enriched 2H-azirine 3-phosphonates and dienes stereoselectively furnish optically pure, bicyclic aziridine adducts that on hydrogenation afford the first examples of enantiopure quaternary pip