40662-12-2Relevant academic research and scientific papers
A Quencher-Fluorophore-Type Probe for Detection and Imaging of NADPH in Human Breast Cancer Cells
Yu, Geunhyeok,Kim, Sungryung,Bae, Se Won,Yeo, Woon-Seok
, p. 807 - 811 (2019)
A new fluorogenic trimethyl lock quinone (TLQ) derivative, designated as the quencher-TLQ-fluorophore-type probe (Q-TLQ-F), was developed for selective detection of nicotinamide adenine dinucleotide phosphate (NADPH). By taking advantage of the well-known facile intramolecular ring cyclization reaction (δ-lactonization) of TLQ that can release a reporter molecule upon reduction, Q-TLQ-F was successfully applied for the detection of physiological NADPH generated by glucose-6-phosphate dehydrogenase in human breast cancer MDA-MB-231 cells.
